Biocompatibility of Nanoparticles: Hematological Effects of Gold Nanorods on Erythrocytes: Hemolysis and Hemoglobin Conformational and Functional Changes (Adv. Sci. 12/2017)

In article 1700296, Qunfang Zhou and co‐workers report the hemocompatibility of gold nanorods (GNRs). In contrast to negatively charged GNRs, positively charged GNRs (C‐GNRs) induce instant hemolysis. After cellular encapsulation, the GNRs are found to bind with hemoglobin and to induce conformation...

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Autores principales: Zhao, Xingchen, Lu, Dawei, Liu, Qian S., Li, Yiling, Feng, Rui, Hao, Fang, Qu, Guangbo, Zhou, Qunfang, Jiang, Guibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Cover Picture
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737327/
http://dx.doi.org/10.1002/advs.201770058
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author Zhao, Xingchen
Lu, Dawei
Liu, Qian S.
Li, Yiling
Feng, Rui
Hao, Fang
Qu, Guangbo
Zhou, Qunfang
Jiang, Guibin
author_facet Zhao, Xingchen
Lu, Dawei
Liu, Qian S.
Li, Yiling
Feng, Rui
Hao, Fang
Qu, Guangbo
Zhou, Qunfang
Jiang, Guibin
author_sort Zhao, Xingchen
collection PubMed
description In article 1700296, Qunfang Zhou and co‐workers report the hemocompatibility of gold nanorods (GNRs). In contrast to negatively charged GNRs, positively charged GNRs (C‐GNRs) induce instant hemolysis. After cellular encapsulation, the GNRs are found to bind with hemoglobin and to induce conformational and functional changes in the protein. This demonstrates that surface modification holds great promise as an approach to improve the biocompatibility of GNRs for clinical use. [Image: see text]
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spelling pubmed-57373272017-12-21 Biocompatibility of Nanoparticles: Hematological Effects of Gold Nanorods on Erythrocytes: Hemolysis and Hemoglobin Conformational and Functional Changes (Adv. Sci. 12/2017) Zhao, Xingchen Lu, Dawei Liu, Qian S. Li, Yiling Feng, Rui Hao, Fang Qu, Guangbo Zhou, Qunfang Jiang, Guibin Adv Sci (Weinh) Cover Picture In article 1700296, Qunfang Zhou and co‐workers report the hemocompatibility of gold nanorods (GNRs). In contrast to negatively charged GNRs, positively charged GNRs (C‐GNRs) induce instant hemolysis. After cellular encapsulation, the GNRs are found to bind with hemoglobin and to induce conformational and functional changes in the protein. This demonstrates that surface modification holds great promise as an approach to improve the biocompatibility of GNRs for clinical use. [Image: see text] John Wiley and Sons Inc. 2017-12-20 /pmc/articles/PMC5737327/ http://dx.doi.org/10.1002/advs.201770058 Text en © 2017 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Cover Picture
Zhao, Xingchen
Lu, Dawei
Liu, Qian S.
Li, Yiling
Feng, Rui
Hao, Fang
Qu, Guangbo
Zhou, Qunfang
Jiang, Guibin
Biocompatibility of Nanoparticles: Hematological Effects of Gold Nanorods on Erythrocytes: Hemolysis and Hemoglobin Conformational and Functional Changes (Adv. Sci. 12/2017)
title Biocompatibility of Nanoparticles: Hematological Effects of Gold Nanorods on Erythrocytes: Hemolysis and Hemoglobin Conformational and Functional Changes (Adv. Sci. 12/2017)
title_full Biocompatibility of Nanoparticles: Hematological Effects of Gold Nanorods on Erythrocytes: Hemolysis and Hemoglobin Conformational and Functional Changes (Adv. Sci. 12/2017)
title_fullStr Biocompatibility of Nanoparticles: Hematological Effects of Gold Nanorods on Erythrocytes: Hemolysis and Hemoglobin Conformational and Functional Changes (Adv. Sci. 12/2017)
title_full_unstemmed Biocompatibility of Nanoparticles: Hematological Effects of Gold Nanorods on Erythrocytes: Hemolysis and Hemoglobin Conformational and Functional Changes (Adv. Sci. 12/2017)
title_short Biocompatibility of Nanoparticles: Hematological Effects of Gold Nanorods on Erythrocytes: Hemolysis and Hemoglobin Conformational and Functional Changes (Adv. Sci. 12/2017)
title_sort biocompatibility of nanoparticles: hematological effects of gold nanorods on erythrocytes: hemolysis and hemoglobin conformational and functional changes (adv. sci. 12/2017)
topic Cover Picture
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737327/
http://dx.doi.org/10.1002/advs.201770058
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