Functional and structural analysis of AT-specific minor groove binders that disrupt DNA–protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast

Trypanosoma brucei, the causative agent of sleeping sickness (Human African Trypanosomiasis, HAT), contains a kinetoplast with the mitochondrial DNA (kDNA), comprising of >70% AT base pairs. This has prompted studies of drugs interacting with AT-rich DNA, such as the N-phenylbenzamide bis(2-amino...

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Detalles Bibliográficos
Autores principales: Millan, Cinthia R., Acosta-Reyes, Francisco J., Lagartera, Laura, Ebiloma, Godwin U., Lemgruber, Leandro, Nué Martínez, J. Jonathan, Saperas, Núria, Dardonville, Christophe, de Koning, Harry P., Campos, J. Lourdes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737332/
https://www.ncbi.nlm.nih.gov/pubmed/28637278
http://dx.doi.org/10.1093/nar/gkx521

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