The FASTK family of proteins: emerging regulators of mitochondrial RNA biology

The FASTK family proteins have recently emerged as key post-transcriptional regulators of mitochondrial gene expression. FASTK, the founding member and its homologs FASTKD1–5 are architecturally related RNA-binding proteins, each having a different function in the regulation of mitochondrial RNA bio...

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Detalles Bibliográficos
Autores principales: Jourdain, Alexis A., Popow, Johannes, de la Fuente, Miguel A., Martinou, Jean-Claude, Anderson, Paul, Simarro, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Survey and Summary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737537/
https://www.ncbi.nlm.nih.gov/pubmed/29036396
http://dx.doi.org/10.1093/nar/gkx772
Descripción
Sumario:The FASTK family proteins have recently emerged as key post-transcriptional regulators of mitochondrial gene expression. FASTK, the founding member and its homologs FASTKD1–5 are architecturally related RNA-binding proteins, each having a different function in the regulation of mitochondrial RNA biology, from mRNA processing and maturation to ribosome assembly and translation. In this review, we outline the structure, evolution and function of these FASTK proteins and discuss the individual role that each has in mitochondrial RNA biology. In addition, we highlight the aspects of FASTK research that still require more attention.

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