The FASTK family of proteins: emerging regulators of mitochondrial RNA biology

The FASTK family proteins have recently emerged as key post-transcriptional regulators of mitochondrial gene expression. FASTK, the founding member and its homologs FASTKD1–5 are architecturally related RNA-binding proteins, each having a different function in the regulation of mitochondrial RNA bio...

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Autores principales: Jourdain, Alexis A., Popow, Johannes, de la Fuente, Miguel A., Martinou, Jean-Claude, Anderson, Paul, Simarro, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Survey and Summary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737537/
https://www.ncbi.nlm.nih.gov/pubmed/29036396
http://dx.doi.org/10.1093/nar/gkx772
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author Jourdain, Alexis A.
Popow, Johannes
de la Fuente, Miguel A.
Martinou, Jean-Claude
Anderson, Paul
Simarro, Maria
author_facet Jourdain, Alexis A.
Popow, Johannes
de la Fuente, Miguel A.
Martinou, Jean-Claude
Anderson, Paul
Simarro, Maria
author_sort Jourdain, Alexis A.
collection PubMed
description The FASTK family proteins have recently emerged as key post-transcriptional regulators of mitochondrial gene expression. FASTK, the founding member and its homologs FASTKD1–5 are architecturally related RNA-binding proteins, each having a different function in the regulation of mitochondrial RNA biology, from mRNA processing and maturation to ribosome assembly and translation. In this review, we outline the structure, evolution and function of these FASTK proteins and discuss the individual role that each has in mitochondrial RNA biology. In addition, we highlight the aspects of FASTK research that still require more attention.
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spelling pubmed-57375372018-01-09 The FASTK family of proteins: emerging regulators of mitochondrial RNA biology Jourdain, Alexis A. Popow, Johannes de la Fuente, Miguel A. Martinou, Jean-Claude Anderson, Paul Simarro, Maria Nucleic Acids Res Survey and Summary The FASTK family proteins have recently emerged as key post-transcriptional regulators of mitochondrial gene expression. FASTK, the founding member and its homologs FASTKD1–5 are architecturally related RNA-binding proteins, each having a different function in the regulation of mitochondrial RNA biology, from mRNA processing and maturation to ribosome assembly and translation. In this review, we outline the structure, evolution and function of these FASTK proteins and discuss the individual role that each has in mitochondrial RNA biology. In addition, we highlight the aspects of FASTK research that still require more attention. Oxford University Press 2017-11-02 2017-09-19 /pmc/articles/PMC5737537/ /pubmed/29036396 http://dx.doi.org/10.1093/nar/gkx772 Text en © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Survey and Summary
Jourdain, Alexis A.
Popow, Johannes
de la Fuente, Miguel A.
Martinou, Jean-Claude
Anderson, Paul
Simarro, Maria
The FASTK family of proteins: emerging regulators of mitochondrial RNA biology
title The FASTK family of proteins: emerging regulators of mitochondrial RNA biology
title_full The FASTK family of proteins: emerging regulators of mitochondrial RNA biology
title_fullStr The FASTK family of proteins: emerging regulators of mitochondrial RNA biology
title_full_unstemmed The FASTK family of proteins: emerging regulators of mitochondrial RNA biology
title_short The FASTK family of proteins: emerging regulators of mitochondrial RNA biology
title_sort fastk family of proteins: emerging regulators of mitochondrial rna biology
topic Survey and Summary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737537/
https://www.ncbi.nlm.nih.gov/pubmed/29036396
http://dx.doi.org/10.1093/nar/gkx772
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