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Abasic and oxidized ribonucleotides embedded in DNA are processed by human APE1 and not by RNase H2

Ribonucleoside 5′-monophosphates (rNMPs) are the most common non-standard nucleotides found in DNA of eukaryotic cells, with over 100 million rNMPs transiently incorporated in the mammalian genome per cell cycle. Human ribonuclease (RNase) H2 is the principal enzyme able to cleave rNMPs in DNA. Whet...

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Detalles Bibliográficos
Autores principales:	Malfatti, Matilde Clarissa, Balachander, Sathya, Antoniali, Giulia, Koh, Kyung Duk, Saint-Pierre, Christine, Gasparutto, Didier, Chon, Hyongi, Crouch, Robert J., Storici, Francesca, Tell, Gianluca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737539/ https://www.ncbi.nlm.nih.gov/pubmed/28977421 http://dx.doi.org/10.1093/nar/gkx723

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