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A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer
TET1 oxidizes methylated cytosine into 5-hydroxymethylcytosine (5hmC), resulting in regulation of DNA methylation and gene expression. Full length TET1 (TET1(FL)) has a CXXC domain that binds to unmethylated CpG islands (CGIs). This CXXC domain allows TET1 to protect CGIs from aberrant methylation,...
Autores principales: | Good, Charly R., Madzo, Jozef, Patel, Bela, Maegawa, Shinji, Engel, Nora, Jelinek, Jaroslav, Issa, Jean-Pierre J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737541/ https://www.ncbi.nlm.nih.gov/pubmed/28531272 http://dx.doi.org/10.1093/nar/gkx435 |
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