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In silico design of context-responsive mammalian promoters with user-defined functionality

Comprehensive de novo-design of complex mammalian promoters is restricted by unpredictable combinatorial interactions between constituent transcription factor regulatory elements (TFREs). In this study, we show that modular binding sites that do not function cooperatively can be identified by analyz...

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Detalles Bibliográficos
Autores principales:	Brown, Adam J., Gibson, Suzanne J., Hatton, Diane, James, David C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Synthetic Biology and Bioengineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737543/ https://www.ncbi.nlm.nih.gov/pubmed/28977454 http://dx.doi.org/10.1093/nar/gkx768

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