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An RNA editing/dsRNA binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer
Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by Adenosine DeAminases acting on double-stranded RNA(dsRNA) (ADAR), occurs predominantly in the 3′ untranslated regions (3′UTRs) of spliced mRNA. Here we uncover an unanticipated link between ADARs (ADAR1 and ADAR2) and the expression of target g...
Autores principales: | Qi, Lihua, Song, Yangyang, Chan, Tim Hon Man, Yang, Henry, Lin, Chi Ho, Tay, Daryl Jin Tai, Hong, HuiQi, Tang, Sze Jing, Tan, Kar Tong, Huang, Xi Xiao, Lin, Jaymie Siqi, Ng, Vanessa Hui En, Maury, Julien Jean Pierre, Tenen, Daniel G., Chen, Leilei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737565/ https://www.ncbi.nlm.nih.gov/pubmed/28985428 http://dx.doi.org/10.1093/nar/gkx667 |
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