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The herpes viral transcription factor ICP4 forms a novel DNA recognition complex

The transcription factor ICP4 from herpes simplex virus has a central role in regulating the gene expression cascade which controls viral infection. Here we present the crystal structure of the functionally essential ICP4 DNA binding domain in complex with a segment from its own promoter, revealing...

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Detalles Bibliográficos
Autores principales:	Tunnicliffe, Richard B., Lockhart-Cairns, Michael P., Levy, Colin, Mould, A. Paul, Jowitt, Thomas A., Sito, Hilary, Baldock, Clair, Sandri-Goldin, Rozanne M., Golovanov, Alexander P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737704/ https://www.ncbi.nlm.nih.gov/pubmed/28505309 http://dx.doi.org/10.1093/nar/gkx419

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