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Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy

While having multiple aminoacyl-tRNA synthetases implicated in Charcot-Marie-Tooth (CMT) disease suggests a common mechanism, a defect in enzymatic activity is not shared among the CMT-causing mutants. Protein misfolding is a common hypothesis underlying the development of many neurological diseases...

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Detalles Bibliográficos
Autores principales:	Blocquel, David, Li, Sheng, Wei, Na, Daub, Herwin, Sajish, Mathew, Erfurth, Maria-Luise, Kooi, Grace, Zhou, Jiadong, Bai, Ge, Schimmel, Paul, Jordanova, Albena, Yang, Xiang-Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737801/ https://www.ncbi.nlm.nih.gov/pubmed/28531329 http://dx.doi.org/10.1093/nar/gkx455

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