Autoregulation of RBM10 and cross-regulation of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay

Mutations in the spliceosomal RNA binding protein RBM10 cause TARP syndrome and are frequently observed in lung adenocarcinoma (LUAD). We have previously shown that RBM10 enhances exon skipping of its target genes, including its paralog RBM5. Here, we report that RBM10 negatively regulates its own m...

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Detalles Bibliográficos
Autores principales: Sun, Yue, Bao, Yufang, Han, Wenjian, Song, Fan, Shen, Xianfeng, Zhao, Jiawei, Zuo, Ji, Saffen, David, Chen, Wei, Wang, Zefeng, You, Xintian, Wang, Yongbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737846/
https://www.ncbi.nlm.nih.gov/pubmed/28586478
http://dx.doi.org/10.1093/nar/gkx508

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