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T7 RNA polymerase translocation is facilitated by a helix opening on the fingers domain that may also prevent backtracking

Here, we studied the complete process of a viral T7 RNA polymerase (RNAP) translocation on DNA during transcription elongation by implementing extensive all-atom molecular dynamics (MD) simulations to construct a Markov state model (MSM). Our studies show that translocation proceeds in a Brownian mo...

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Detalles Bibliográficos
Autores principales:	Da, Lin-Tai, E, Chao, Shuai, Yao, Wu, Shaogui, Su, Xiao-Dong, Yu, Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737862/ https://www.ncbi.nlm.nih.gov/pubmed/28575393 http://dx.doi.org/10.1093/nar/gkx495

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