S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells

The Hodgkin/Reed–Sternberg cells of classical Hodgkin lymphoma (HL) are characterised by the aberrant activation of multiple signalling pathways. Here we show that a subset of HL displays altered expression of sphingosine-1-phosphate (S1P) receptors (S1PR)s. S1P activates phosphatidylinositide 3-kin...

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Detalles Bibliográficos
Autores principales: Vrzalikova, K, Ibrahim, M, Vockerodt, M, Perry, T, Margielewska, S, Lupino, L, Nagy, E, Soilleux, E, Liebelt, D, Hollows, R, Last, A, Reynolds, G, Abdullah, M, Curley, H, Care, M, Krappmann, D, Tooze, R, Allegood, J, Spiegel, S, Wei, W, Woodman, C B J, Murray, P G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737877/
https://www.ncbi.nlm.nih.gov/pubmed/28878352
http://dx.doi.org/10.1038/leu.2017.275

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