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Late presentation of necrotizing enterocolitis associated with rotavirus infection in a term infant with hyperinsulinism on octreotide therapy: A case report

RATIONALE: Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infancy that can cause permanent brain damage. Consequently, optimal management is extremely important. Current pharmacologic and surgical treatment were available that included diazoxide and octreotid...

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Autores principales: Alsaedi, Abdulaziz A., Bakkar, Ayman A., Kamal, Naglaa M., Althobiti, Jwaher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737990/
https://www.ncbi.nlm.nih.gov/pubmed/28984754
http://dx.doi.org/10.1097/MD.0000000000007949
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author Alsaedi, Abdulaziz A.
Bakkar, Ayman A.
Kamal, Naglaa M.
Althobiti, Jwaher M.
author_facet Alsaedi, Abdulaziz A.
Bakkar, Ayman A.
Kamal, Naglaa M.
Althobiti, Jwaher M.
author_sort Alsaedi, Abdulaziz A.
collection PubMed
description RATIONALE: Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infancy that can cause permanent brain damage. Consequently, optimal management is extremely important. Current pharmacologic and surgical treatment were available that included diazoxide and octreotides. PATIENT CONCERNS: A 4 month old Saudi male patient diagnosed at our hospital as CHI, treated with near total pancreatectomy and octreotide therapy of 30 mcg/kg/day presented with severe abdominal distension, vomiting and bloody diarrhea. DIAGNOSES: The patient was diagnosed as necrotising enterocolitis (NEC) associated with Rota virus infection which played together with octeriotides as risk factors for NEC. INTERVENTIONS: Radiological investigations and multidisciplinary team management with endocrinologist, neonatologist, pediatric surgeon, and gastroenterologist. OUTCOMES: Resolution of NEC with conservative medical management and was discharged after 1 month of hospital stay with follow up with all concerned sub specialties. LESSONS: NEC can develop in patients treated with octreotides especially when associated with another risk factor such as rotavirus infection.
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spelling pubmed-57379902018-01-02 Late presentation of necrotizing enterocolitis associated with rotavirus infection in a term infant with hyperinsulinism on octreotide therapy: A case report Alsaedi, Abdulaziz A. Bakkar, Ayman A. Kamal, Naglaa M. Althobiti, Jwaher M. Medicine (Baltimore) 6200 RATIONALE: Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infancy that can cause permanent brain damage. Consequently, optimal management is extremely important. Current pharmacologic and surgical treatment were available that included diazoxide and octreotides. PATIENT CONCERNS: A 4 month old Saudi male patient diagnosed at our hospital as CHI, treated with near total pancreatectomy and octreotide therapy of 30 mcg/kg/day presented with severe abdominal distension, vomiting and bloody diarrhea. DIAGNOSES: The patient was diagnosed as necrotising enterocolitis (NEC) associated with Rota virus infection which played together with octeriotides as risk factors for NEC. INTERVENTIONS: Radiological investigations and multidisciplinary team management with endocrinologist, neonatologist, pediatric surgeon, and gastroenterologist. OUTCOMES: Resolution of NEC with conservative medical management and was discharged after 1 month of hospital stay with follow up with all concerned sub specialties. LESSONS: NEC can develop in patients treated with octreotides especially when associated with another risk factor such as rotavirus infection. Wolters Kluwer Health 2017-10-27 /pmc/articles/PMC5737990/ /pubmed/28984754 http://dx.doi.org/10.1097/MD.0000000000007949 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 6200
Alsaedi, Abdulaziz A.
Bakkar, Ayman A.
Kamal, Naglaa M.
Althobiti, Jwaher M.
Late presentation of necrotizing enterocolitis associated with rotavirus infection in a term infant with hyperinsulinism on octreotide therapy: A case report
title Late presentation of necrotizing enterocolitis associated with rotavirus infection in a term infant with hyperinsulinism on octreotide therapy: A case report
title_full Late presentation of necrotizing enterocolitis associated with rotavirus infection in a term infant with hyperinsulinism on octreotide therapy: A case report
title_fullStr Late presentation of necrotizing enterocolitis associated with rotavirus infection in a term infant with hyperinsulinism on octreotide therapy: A case report
title_full_unstemmed Late presentation of necrotizing enterocolitis associated with rotavirus infection in a term infant with hyperinsulinism on octreotide therapy: A case report
title_short Late presentation of necrotizing enterocolitis associated with rotavirus infection in a term infant with hyperinsulinism on octreotide therapy: A case report
title_sort late presentation of necrotizing enterocolitis associated with rotavirus infection in a term infant with hyperinsulinism on octreotide therapy: a case report
topic 6200
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737990/
https://www.ncbi.nlm.nih.gov/pubmed/28984754
http://dx.doi.org/10.1097/MD.0000000000007949
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