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A case report of tongue metastasis from lung squamous cell carcinoma and literature review
RATIONALE: Tongue metastasis from lung cancer is extremely rare, and the prognosis of these patients is rather poor. PATIENT CONCERS: A 56-year-old man was found a 4-cm cavity lesion in the left upper lobe, which was initially misdiagnosed as tuberculosis. DIAGNOSES: A case of lung squamous cell car...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738010/ https://www.ncbi.nlm.nih.gov/pubmed/28984774 http://dx.doi.org/10.1097/MD.0000000000008208 |
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author | Cheng, Xiaolong Hu, Zhenli Han, Yipin Bai, Chong |
author_facet | Cheng, Xiaolong Hu, Zhenli Han, Yipin Bai, Chong |
author_sort | Cheng, Xiaolong |
collection | PubMed |
description | RATIONALE: Tongue metastasis from lung cancer is extremely rare, and the prognosis of these patients is rather poor. PATIENT CONCERS: A 56-year-old man was found a 4-cm cavity lesion in the left upper lobe, which was initially misdiagnosed as tuberculosis. DIAGNOSES: A case of lung squamous cell carcinoma that metastasized to the base of a patient's tongue. INTERVATIONS: We send the biopsy of the lung and the tongue lesions for gene sequencing. OUTCOMES: He received systemic chemotherapy, but continued to have pain at the base of his tongue and died 7 months later. LESSONS: From sequencing data, mutations in KRAS proto-oncogene, GTPase (KRAS), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), and tumor protein p53 (TP53) were found in the tumor biopsy of the patient. All of these were indicators of poor prognosis. |
format | Online Article Text |
id | pubmed-5738010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-57380102018-01-02 A case report of tongue metastasis from lung squamous cell carcinoma and literature review Cheng, Xiaolong Hu, Zhenli Han, Yipin Bai, Chong Medicine (Baltimore) 5700 RATIONALE: Tongue metastasis from lung cancer is extremely rare, and the prognosis of these patients is rather poor. PATIENT CONCERS: A 56-year-old man was found a 4-cm cavity lesion in the left upper lobe, which was initially misdiagnosed as tuberculosis. DIAGNOSES: A case of lung squamous cell carcinoma that metastasized to the base of a patient's tongue. INTERVATIONS: We send the biopsy of the lung and the tongue lesions for gene sequencing. OUTCOMES: He received systemic chemotherapy, but continued to have pain at the base of his tongue and died 7 months later. LESSONS: From sequencing data, mutations in KRAS proto-oncogene, GTPase (KRAS), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), and tumor protein p53 (TP53) were found in the tumor biopsy of the patient. All of these were indicators of poor prognosis. Wolters Kluwer Health 2017-10-27 /pmc/articles/PMC5738010/ /pubmed/28984774 http://dx.doi.org/10.1097/MD.0000000000008208 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0 |
spellingShingle | 5700 Cheng, Xiaolong Hu, Zhenli Han, Yipin Bai, Chong A case report of tongue metastasis from lung squamous cell carcinoma and literature review |
title | A case report of tongue metastasis from lung squamous cell carcinoma and literature review |
title_full | A case report of tongue metastasis from lung squamous cell carcinoma and literature review |
title_fullStr | A case report of tongue metastasis from lung squamous cell carcinoma and literature review |
title_full_unstemmed | A case report of tongue metastasis from lung squamous cell carcinoma and literature review |
title_short | A case report of tongue metastasis from lung squamous cell carcinoma and literature review |
title_sort | case report of tongue metastasis from lung squamous cell carcinoma and literature review |
topic | 5700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738010/ https://www.ncbi.nlm.nih.gov/pubmed/28984774 http://dx.doi.org/10.1097/MD.0000000000008208 |
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