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The multistep road to ventilator-associated lung abscess: A retrospective study of S.aureus ventilator-associated pneumonia
OBJECT: We observed some cases of lung abscess (LA) in ICU patients suffering S.aureus ventilator-associated pneumonia (S.aureus-VAP). We aimed to assess which of the host and/or bacteria-related features are associated with LA. METHODS: We conducted a retrospective study from January 2009 to July 2...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738060/ https://www.ncbi.nlm.nih.gov/pubmed/29261721 http://dx.doi.org/10.1371/journal.pone.0189249 |
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author | Mounier, Roman Lobo, David Voulgaropoulos, Julia Martin, Mathieu Aït-Mamar, Bouziane Bitot, Valérie Jost, Paul-Henri Birnbaum, Ron Nebbad, Biba Cook, Fabrice Dhonneur, Gilles |
author_facet | Mounier, Roman Lobo, David Voulgaropoulos, Julia Martin, Mathieu Aït-Mamar, Bouziane Bitot, Valérie Jost, Paul-Henri Birnbaum, Ron Nebbad, Biba Cook, Fabrice Dhonneur, Gilles |
author_sort | Mounier, Roman |
collection | PubMed |
description | OBJECT: We observed some cases of lung abscess (LA) in ICU patients suffering S.aureus ventilator-associated pneumonia (S.aureus-VAP). We aimed to assess which of the host and/or bacteria-related features are associated with LA. METHODS: We conducted a retrospective study from January 2009 to July 2013 in a trauma surgical ICU within a teaching hospital. All adult patients presenting with S.aureus-VAP were included. We compared two groups of patients according to the formation or not of LA concomitantly to S.aureus-VAP. RESULTS: Seventy-nine S.aureus-VAP patients, predominantly males (85%) of rather young age (mean [SD]: 35yr [21–64]) with severe trauma (initial Simplified Acute Score II = 42 [32–52]) related-ICU admission, were included. Among them, 10 (14%) developed LA. Patient’s characteristics significantly associated with LA development were: a younger age (p = 0.003), road traffic accidents admission (p = 0.017), head injury (p = 0.002), lower Glasgow Coma Scale (p = 0.009), blunt chest trauma (p = 0.01) pneumothorax (p = 0.01) and lung contusions (p = 0.002). No microbiological factors were significantly associated with LA formation. Abscesses were mostly bilateral, ≥5 cm of diameter and with a posterior location. CONCLUSIONS: Our results do not favor a specific virulence of S.aureus, but rather highlight the role of multiple insults to the lung, promoting LA formation. Despite a similar severity score, patients with LA had more serious trauma, combining severe both chest and head insults. |
format | Online Article Text |
id | pubmed-5738060 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-57380602017-12-29 The multistep road to ventilator-associated lung abscess: A retrospective study of S.aureus ventilator-associated pneumonia Mounier, Roman Lobo, David Voulgaropoulos, Julia Martin, Mathieu Aït-Mamar, Bouziane Bitot, Valérie Jost, Paul-Henri Birnbaum, Ron Nebbad, Biba Cook, Fabrice Dhonneur, Gilles PLoS One Research Article OBJECT: We observed some cases of lung abscess (LA) in ICU patients suffering S.aureus ventilator-associated pneumonia (S.aureus-VAP). We aimed to assess which of the host and/or bacteria-related features are associated with LA. METHODS: We conducted a retrospective study from January 2009 to July 2013 in a trauma surgical ICU within a teaching hospital. All adult patients presenting with S.aureus-VAP were included. We compared two groups of patients according to the formation or not of LA concomitantly to S.aureus-VAP. RESULTS: Seventy-nine S.aureus-VAP patients, predominantly males (85%) of rather young age (mean [SD]: 35yr [21–64]) with severe trauma (initial Simplified Acute Score II = 42 [32–52]) related-ICU admission, were included. Among them, 10 (14%) developed LA. Patient’s characteristics significantly associated with LA development were: a younger age (p = 0.003), road traffic accidents admission (p = 0.017), head injury (p = 0.002), lower Glasgow Coma Scale (p = 0.009), blunt chest trauma (p = 0.01) pneumothorax (p = 0.01) and lung contusions (p = 0.002). No microbiological factors were significantly associated with LA formation. Abscesses were mostly bilateral, ≥5 cm of diameter and with a posterior location. CONCLUSIONS: Our results do not favor a specific virulence of S.aureus, but rather highlight the role of multiple insults to the lung, promoting LA formation. Despite a similar severity score, patients with LA had more serious trauma, combining severe both chest and head insults. Public Library of Science 2017-12-20 /pmc/articles/PMC5738060/ /pubmed/29261721 http://dx.doi.org/10.1371/journal.pone.0189249 Text en © 2017 Mounier et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Mounier, Roman Lobo, David Voulgaropoulos, Julia Martin, Mathieu Aït-Mamar, Bouziane Bitot, Valérie Jost, Paul-Henri Birnbaum, Ron Nebbad, Biba Cook, Fabrice Dhonneur, Gilles The multistep road to ventilator-associated lung abscess: A retrospective study of S.aureus ventilator-associated pneumonia |
title | The multistep road to ventilator-associated lung abscess: A retrospective study of S.aureus ventilator-associated pneumonia |
title_full | The multistep road to ventilator-associated lung abscess: A retrospective study of S.aureus ventilator-associated pneumonia |
title_fullStr | The multistep road to ventilator-associated lung abscess: A retrospective study of S.aureus ventilator-associated pneumonia |
title_full_unstemmed | The multistep road to ventilator-associated lung abscess: A retrospective study of S.aureus ventilator-associated pneumonia |
title_short | The multistep road to ventilator-associated lung abscess: A retrospective study of S.aureus ventilator-associated pneumonia |
title_sort | multistep road to ventilator-associated lung abscess: a retrospective study of s.aureus ventilator-associated pneumonia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738060/ https://www.ncbi.nlm.nih.gov/pubmed/29261721 http://dx.doi.org/10.1371/journal.pone.0189249 |
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