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Prognostic significance of microvascular invasion in tumor stage for hepatocellular carcinoma
BACKGROUND: The presence of microvascular invasion (McVI) in hepatocellular carcinoma (HCC) has been proposed as a cause of recurrence and poor survival, although this has not been officially emphasized in staging systems. Thus, we conducted a retrospective study to investigate the prognostic import...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738148/ https://www.ncbi.nlm.nih.gov/pubmed/29258507 http://dx.doi.org/10.1186/s12957-017-1292-3 |
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author | Park, Yong Keun Song, Sung Kyu Kim, Bong-Wan Park, Seung-Keun Chung, Chul-Woon Wang, Hee-Jung |
author_facet | Park, Yong Keun Song, Sung Kyu Kim, Bong-Wan Park, Seung-Keun Chung, Chul-Woon Wang, Hee-Jung |
author_sort | Park, Yong Keun |
collection | PubMed |
description | BACKGROUND: The presence of microvascular invasion (McVI) in hepatocellular carcinoma (HCC) has been proposed as a cause of recurrence and poor survival, although this has not been officially emphasized in staging systems. Thus, we conducted a retrospective study to investigate the prognostic importance of McVI in tumor staging in patients with HCC who underwent hepatic resection. METHODS: A retrospective analysis was performed of patients who underwent hepatic resection for HCC at our center from 1994 to 2012. Patients with HCC were classified into four groups based on the presence of McVI and extent of gross vascular invasion (VI). RESULTS: The 5-year overall and recurrence-free survival rates of 676 patients were 63.3 and 42.6%, respectively. There was no difference in tumor recurrence or survival rate between patients with HCC and McVI without gross VI and those with gross VI confined to segmental/sectional branches. Multivariate analysis revealed that the extent of VI based on the presence of McVI and gross VI was independently associated with tumor recurrence and overall survival. CONCLUSIONS: McVI was revealed to be an important risk factor similar to gross VI confined to a segmental/sectional branch in patients with HCC who underwent hepatic resection. This finding should be considered when estimating the stage for prognosis. |
format | Online Article Text |
id | pubmed-5738148 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-57381482017-12-21 Prognostic significance of microvascular invasion in tumor stage for hepatocellular carcinoma Park, Yong Keun Song, Sung Kyu Kim, Bong-Wan Park, Seung-Keun Chung, Chul-Woon Wang, Hee-Jung World J Surg Oncol Research BACKGROUND: The presence of microvascular invasion (McVI) in hepatocellular carcinoma (HCC) has been proposed as a cause of recurrence and poor survival, although this has not been officially emphasized in staging systems. Thus, we conducted a retrospective study to investigate the prognostic importance of McVI in tumor staging in patients with HCC who underwent hepatic resection. METHODS: A retrospective analysis was performed of patients who underwent hepatic resection for HCC at our center from 1994 to 2012. Patients with HCC were classified into four groups based on the presence of McVI and extent of gross vascular invasion (VI). RESULTS: The 5-year overall and recurrence-free survival rates of 676 patients were 63.3 and 42.6%, respectively. There was no difference in tumor recurrence or survival rate between patients with HCC and McVI without gross VI and those with gross VI confined to segmental/sectional branches. Multivariate analysis revealed that the extent of VI based on the presence of McVI and gross VI was independently associated with tumor recurrence and overall survival. CONCLUSIONS: McVI was revealed to be an important risk factor similar to gross VI confined to a segmental/sectional branch in patients with HCC who underwent hepatic resection. This finding should be considered when estimating the stage for prognosis. BioMed Central 2017-12-19 /pmc/articles/PMC5738148/ /pubmed/29258507 http://dx.doi.org/10.1186/s12957-017-1292-3 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Park, Yong Keun Song, Sung Kyu Kim, Bong-Wan Park, Seung-Keun Chung, Chul-Woon Wang, Hee-Jung Prognostic significance of microvascular invasion in tumor stage for hepatocellular carcinoma |
title | Prognostic significance of microvascular invasion in tumor stage for hepatocellular carcinoma |
title_full | Prognostic significance of microvascular invasion in tumor stage for hepatocellular carcinoma |
title_fullStr | Prognostic significance of microvascular invasion in tumor stage for hepatocellular carcinoma |
title_full_unstemmed | Prognostic significance of microvascular invasion in tumor stage for hepatocellular carcinoma |
title_short | Prognostic significance of microvascular invasion in tumor stage for hepatocellular carcinoma |
title_sort | prognostic significance of microvascular invasion in tumor stage for hepatocellular carcinoma |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738148/ https://www.ncbi.nlm.nih.gov/pubmed/29258507 http://dx.doi.org/10.1186/s12957-017-1292-3 |
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