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Mini-review on initiatives to interfere with the propagation and clearance of alpha-synuclein in Parkinson’s disease

In this mini-review, we summarize recent findings relating to the prion-like propagation of α-synuclein (α-syn) and the development of novel therapeutic strategies to target synucleinopathy in Parkinson’s disease (PD). We link the Braak’s staging hypothesis of PD with the recent evidence from in-viv...

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Autores principales: Chan, Daniel Kam Yin, Xu, Ying Hua, Chan, Luke Kar Man, Braidy, Nady, Mellick, George D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738184/
https://www.ncbi.nlm.nih.gov/pubmed/29270291
http://dx.doi.org/10.1186/s40035-017-0104-6
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author Chan, Daniel Kam Yin
Xu, Ying Hua
Chan, Luke Kar Man
Braidy, Nady
Mellick, George D.
author_facet Chan, Daniel Kam Yin
Xu, Ying Hua
Chan, Luke Kar Man
Braidy, Nady
Mellick, George D.
author_sort Chan, Daniel Kam Yin
collection PubMed
description In this mini-review, we summarize recent findings relating to the prion-like propagation of α-synuclein (α-syn) and the development of novel therapeutic strategies to target synucleinopathy in Parkinson’s disease (PD). We link the Braak’s staging hypothesis of PD with the recent evidence from in-vivo and in-vitro studies for the prion-like cell-to-cell propagation of α-syn (via exocytosis and endocytosis). The classical accumulation of aggregated α-syn in PD may result from an increased production or a failure in the mechanisms of clearance of α-syn. We discuss novel agents, currently in clinical trial for PD including the ones that impact the aggregation of α-syn and others that interfere with α-syn endocytosis as a means to target the progression of the disease.
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spelling pubmed-57381842017-12-21 Mini-review on initiatives to interfere with the propagation and clearance of alpha-synuclein in Parkinson’s disease Chan, Daniel Kam Yin Xu, Ying Hua Chan, Luke Kar Man Braidy, Nady Mellick, George D. Transl Neurodegener Review In this mini-review, we summarize recent findings relating to the prion-like propagation of α-synuclein (α-syn) and the development of novel therapeutic strategies to target synucleinopathy in Parkinson’s disease (PD). We link the Braak’s staging hypothesis of PD with the recent evidence from in-vivo and in-vitro studies for the prion-like cell-to-cell propagation of α-syn (via exocytosis and endocytosis). The classical accumulation of aggregated α-syn in PD may result from an increased production or a failure in the mechanisms of clearance of α-syn. We discuss novel agents, currently in clinical trial for PD including the ones that impact the aggregation of α-syn and others that interfere with α-syn endocytosis as a means to target the progression of the disease. BioMed Central 2017-12-20 /pmc/articles/PMC5738184/ /pubmed/29270291 http://dx.doi.org/10.1186/s40035-017-0104-6 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Chan, Daniel Kam Yin
Xu, Ying Hua
Chan, Luke Kar Man
Braidy, Nady
Mellick, George D.
Mini-review on initiatives to interfere with the propagation and clearance of alpha-synuclein in Parkinson’s disease
title Mini-review on initiatives to interfere with the propagation and clearance of alpha-synuclein in Parkinson’s disease
title_full Mini-review on initiatives to interfere with the propagation and clearance of alpha-synuclein in Parkinson’s disease
title_fullStr Mini-review on initiatives to interfere with the propagation and clearance of alpha-synuclein in Parkinson’s disease
title_full_unstemmed Mini-review on initiatives to interfere with the propagation and clearance of alpha-synuclein in Parkinson’s disease
title_short Mini-review on initiatives to interfere with the propagation and clearance of alpha-synuclein in Parkinson’s disease
title_sort mini-review on initiatives to interfere with the propagation and clearance of alpha-synuclein in parkinson’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738184/
https://www.ncbi.nlm.nih.gov/pubmed/29270291
http://dx.doi.org/10.1186/s40035-017-0104-6
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