Cargando…

Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis

VEGFR-2/Notch signalling regulates angiogenesis in part by driving the remodelling of endothelial cell junctions and by inducing cell migration. Here, we show that VEGF-induced polarized cell elongation increases cell perimeter and decreases the relative VE-cadherin concentration at junctions, trigg...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cao, Jiahui, Ehling, Manuel, März, Sigrid, Seebach, Jochen, Tarbashevich, Katsiaryna, Sixta, Tomas, Pitulescu, Mara E., Werner, Ann-Cathrin, Flach, Boris, Montanez, Eloi, Raz, Erez, Adams, Ralf H., Schnittler, Hans
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738342/ https://www.ncbi.nlm.nih.gov/pubmed/29263363 http://dx.doi.org/10.1038/s41467-017-02373-8

Ejemplares similares

Quantitative dynamics of VE-cadherin at endothelial cell junctions at a glance: basic requirements and current concepts
por: Seebach, Jochen, et al.
Publicado: (2016)

E-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow
por: Grimaldi, Cecilia, et al.
Publicado: (2020)

ARP2/3-mediated junction-associated lamellipodia control VE-cadherin–based cell junction dynamics and maintain monolayer integrity
por: Taha, Abdallah Abu, et al.
Publicado: (2014)

Coronin 1B Controls Endothelial Actin Dynamics at Cell–Cell Junctions and Is Required for Endothelial Network Assembly
por: Werner, Ann-Cathrin, et al.
Publicado: (2020)

Coordinated linear and rotational movements of endothelial cells compartmentalized by VE-cadherin drive angiogenic sprouting
por: Tonami, Kazuo, et al.
Publicado: (2023)

The mitochondrial protein Sod2 is important for the migration, maintenance, and fitness of germ cells
por: Tarbashevich, Katsiaryna, et al.
Publicado: (2023)

Differential Localization of VE- and N-Cadherins in Human Endothelial Cells: VE-Cadherin Competes with N-Cadherin for Junctional Localization
por: Navarro, Pilar, et al.
Publicado: (1998)

The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling
por: Giampietro, Costanza, et al.
Publicado: (2015)

Retention of paternal DNA methylome in the developing zebrafish germline
por: Skvortsova, Ksenia, et al.
Publicado: (2019)

How VE-cadherin goes with the flow
por: Short, Ben
Publicado: (2015)

Primordial germ cells adjust their protrusion type while migrating in different tissue contexts in vivo
por: Truszkowski, Lukasz, et al.
Publicado: (2023)

Combined effects of shear stress and glucose on the morphology, actin filaments, and VE-cadherin of endothelial cells in vitro
por: Sulistyowati, Erna, et al.
Publicado: (2017)

N-cadherin acts upstream of VE-cadherin in controlling vascular morphogenesis
por: Luo, Yang, et al.
Publicado: (2005)

Changes in expression of VE-cadherin and MMPs in endothelial cells: Implications for angiogenesis
por: Kiran, Manikantan S, et al.
Publicado: (2011)

Molecular mechanism of VE-cadherin in regulating endothelial cell behaviour during angiogenesis
por: Nan, Weijin, et al.
Publicado: (2023)

Actinomyosin Contraction, Phosphorylation of VE-Cadherin, and Actin Remodeling Enable Melanoma-Induced Endothelial Cell-Cell Junction Disassembly
por: Weidert, Eric, et al.
Publicado: (2014)

Endothelial Phosphatase VE-PTP Participates in Vasculogenic Mimicry by Preventing Autophagic Degradation of VE-Cadherin
por: Delgado-Bellido, Daniel, et al.
Publicado: (2020)

Endothelial permeability and VE-cadherin: A wacky comradeship
por: Gavard, Julie
Publicado: (2014)

VE-Cadherin Is Required for Lymphatic Valve Formation and Maintenance
por: Yang, Ying, et al.
Publicado: (2019)

Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin
por: Frye, Maike, et al.
Publicado: (2015)

VE-PTP stabilizes VE-cadherin junctions and the endothelial barrier via a phosphatase-independent mechanism
por: Juettner, Vanessa V., et al.
Publicado: (2019)

Endothelial barrier dysfunction in systemic inflammation is mediated by soluble VE-cadherin interfering VE-PTP signaling
por: Knop, Juna-Lisa, et al.
Publicado: (2023)

VE-Cadherin in Cancer-Associated Angiogenesis: A Deceptive Strategy of Blood Vessel Formation
por: Delgado-Bellido, Daniel, et al.
Publicado: (2023)

VE-Cadherin–Mediated Epigenetic Regulation of Endothelial Gene Expression
por: Morini, Marco F., et al.
Publicado: (2018)

Antitumor immunity induced by VE-cadherin modified DC vaccine
por: Zhou, Jing, et al.
Publicado: (2017)

Mechanisms Ensuring Endothelial Junction Integrity Beyond VE-Cadherin
por: Duong, Cao Nguyen, et al.
Publicado: (2020)

Extracellular matrix regulates force transduction at VE-cadherin junctions
por: Kong, Xinyu, et al.
Publicado: (2022)

VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF
por: Nottebaum, Astrid F., et al.
Publicado: (2008)

Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo
por: Broermann, Andre, et al.
Publicado: (2011)

Dynamic filopodia are required for chemokine-dependent intracellular polarization during guided cell migration in vivo
por: Meyen, Dana, et al.
Publicado: (2015)

Occurrence of Transmembrane Protein 119 in the Retina is Not Restricted to the Microglia: An Immunohistochemical Study
por: Su, Nan, et al.
Publicado: (2019)

Intermedin promotes vessel fusion by inducing VE‐cadherin accumulation at potential fusion sites and to achieve a dynamic balance between VE‐cadherin‐complex dissociation/reconstitution
por: Kong, Lingmiao, et al.
Publicado: (2020)

VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling
por: Benn, Andreas, et al.
Publicado: (2016)

The VE-cadherin cytoplasmic domain undergoes proteolytic processing during endocytosis
por: Su, Wenji, et al.
Publicado: (2017)

Desacetylvinblastine Monohydrazide Disrupts Tumor Vessels by Promoting VE-cadherin Internalization
por: Lei, Xueping, et al.
Publicado: (2018)

Vasculogenic mimicry signaling revisited: focus on non-vascular VE-cadherin
por: Delgado-Bellido, Daniel, et al.
Publicado: (2017)

VE-cadherin endocytosis controls vascular integrity and patterning during development
por: Grimsley-Myers, Cynthia M., et al.
Publicado: (2020)

GSTpi regulates VE-cadherin stabilization through promoting S-glutathionylation of Src
por: Yang, Yang, et al.
Publicado: (2019)

6-Gingerol stabilized the p-VEGFR2/VE-cadherin/β-catenin/actin complex promotes microvessel normalization and suppresses tumor progression
por: Zhong, Weilong, et al.
Publicado: (2019)

Autoregulatory “Multitasking” at Endothelial Cell Junctions by Junction-Associated Intermittent Lamellipodia Controls Barrier Properties
por: Seebach, Jochen, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_0ia1hdjctv34l723arfj0q96i2