Enrichment of megabase-sized DNA molecules for single-molecule optical mapping and next-generation sequencing

Next-generation sequencing (NGS) has caused a revolution, yet left a gap: long-range genetic information from native, non-amplified DNA fragments is unavailable. It might be obtained by optical mapping of megabase-sized DNA molecules. Frequently only a specific genomic region is of interest, so here...

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Detalles Bibliográficos
Autores principales: Łopacińska-Jørgensen, Joanna M., Pedersen, Jonas N., Bak, Mads, Mehrjouy, Mana M., Sørensen, Kristian T., Østergaard, Peter F., Bilenberg, Brian, Kristensen, Anders, Taboryski, Rafael J., Flyvbjerg, Henrik, Marie, Rodolphe, Tommerup, Niels, Silahtaroglu, Asli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738345/
https://www.ncbi.nlm.nih.gov/pubmed/29263336
http://dx.doi.org/10.1038/s41598-017-18091-6

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