Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway

Nuclear factor (erythroid-derived 2)-like 2 and its Caenorhabditis elegans ortholog, SKN-1, are transcription factors that have a pivotal role in the oxidative stress response, cellular homeostasis, and organismal lifespan. Similar to other defense systems, the NRF2-mediated stress response is compr...

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Detalles Bibliográficos
Autores principales: Dehghan, Esmaeil, Zhang, Yiqiang, Saremi, Bahar, Yadavali, Sivaramakrishna, Hakimi, Amirmansoor, Dehghani, Maryam, Goodarzi, Mohammad, Tu, Xiaoqin, Robertson, Scott, Lin, Rueyling, Chudhuri, Asish, Mirzaei, Hamid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738364/
https://www.ncbi.nlm.nih.gov/pubmed/29263362
http://dx.doi.org/10.1038/s41467-017-02394-3

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