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Evaluating single molecule detection methods for microarrays with high dynamic range for quantitative single cell analysis
Single molecule microarrays have been used in quantitative proteomics, in particular, single cell analysis requiring high sensitivity and ultra-low limits of detection. In this paper, several image analysis methods are evaluated for their ability to accurately enumerate single molecules bound to a m...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738400/ https://www.ncbi.nlm.nih.gov/pubmed/29263350 http://dx.doi.org/10.1038/s41598-017-18303-z |