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Hydrocortisone administration was associated with improved survival in Japanese patients with cardiac arrest

There are few reports on hydrocortisone administration after cardiac arrest, and those that have been published included few subjects. This study aimed to evaluate the effect of hydrocortisone administration on the outcomes of patients who experienced cardiac arrest. We investigated the survival dis...

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Autores principales: Niimura, Takahiro, Zamami, Yoshito, Koyama, Toshihiro, Izawa-Ishizawa, Yuki, Miyake, Masashi, Koga, Tadashi, Harada, Keisaku, Ohshima, Ayako, Imai, Toru, Kondo, Yutaka, Imanishi, Masaki, Takechi, Kenshi, Fukushima, Keijo, Horinouchi, Yuya, Ikeda, Yasumasa, Fujino, Hiromichi, Tsuchiya, Koichiro, Tamaki, Toshiaki, Hinotsu, Shiro, Kano, Mitsunobu R., Ishizawa, Keisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738407/
https://www.ncbi.nlm.nih.gov/pubmed/29263333
http://dx.doi.org/10.1038/s41598-017-17686-3
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author Niimura, Takahiro
Zamami, Yoshito
Koyama, Toshihiro
Izawa-Ishizawa, Yuki
Miyake, Masashi
Koga, Tadashi
Harada, Keisaku
Ohshima, Ayako
Imai, Toru
Kondo, Yutaka
Imanishi, Masaki
Takechi, Kenshi
Fukushima, Keijo
Horinouchi, Yuya
Ikeda, Yasumasa
Fujino, Hiromichi
Tsuchiya, Koichiro
Tamaki, Toshiaki
Hinotsu, Shiro
Kano, Mitsunobu R.
Ishizawa, Keisuke
author_facet Niimura, Takahiro
Zamami, Yoshito
Koyama, Toshihiro
Izawa-Ishizawa, Yuki
Miyake, Masashi
Koga, Tadashi
Harada, Keisaku
Ohshima, Ayako
Imai, Toru
Kondo, Yutaka
Imanishi, Masaki
Takechi, Kenshi
Fukushima, Keijo
Horinouchi, Yuya
Ikeda, Yasumasa
Fujino, Hiromichi
Tsuchiya, Koichiro
Tamaki, Toshiaki
Hinotsu, Shiro
Kano, Mitsunobu R.
Ishizawa, Keisuke
author_sort Niimura, Takahiro
collection PubMed
description There are few reports on hydrocortisone administration after cardiac arrest, and those that have been published included few subjects. This study aimed to evaluate the effect of hydrocortisone administration on the outcomes of patients who experienced cardiac arrest. We investigated the survival discharge rates and the length of hospital stay from cardiac arrest to discharge, stratified by use of hydrocortisone, using a Japanese health-insurance claims dataset that covers approximately 2% of the Japanese population. The study included the data of 2233 subjects who experienced either in-hospital or out-of-hospital cardiac arrest between January 2005 and May 2014. These patients were divided into two groups, based on the administration of hydrocortisone. We adjusted the baseline characteristics, medical treatment, and drug administration data of the two groups using propensity scores obtained via the inverse probability of treatment weighted method. The hydrocortisone group had a significantly higher survival discharge rate (13/61 [21.1%] vs. 240/2172 [11.0%], adjusted odds ratio: 4.2, 95% CI: 1.60–10.98, p = 0.004). In addition, the administration of hydrocortisone was independent predictor of survival to discharge (hazard ratio: 4.6, p < 0.001). The results demonstrate a correlation between hydrocortisone administration and the high rates of survival to discharge.
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spelling pubmed-57384072017-12-22 Hydrocortisone administration was associated with improved survival in Japanese patients with cardiac arrest Niimura, Takahiro Zamami, Yoshito Koyama, Toshihiro Izawa-Ishizawa, Yuki Miyake, Masashi Koga, Tadashi Harada, Keisaku Ohshima, Ayako Imai, Toru Kondo, Yutaka Imanishi, Masaki Takechi, Kenshi Fukushima, Keijo Horinouchi, Yuya Ikeda, Yasumasa Fujino, Hiromichi Tsuchiya, Koichiro Tamaki, Toshiaki Hinotsu, Shiro Kano, Mitsunobu R. Ishizawa, Keisuke Sci Rep Article There are few reports on hydrocortisone administration after cardiac arrest, and those that have been published included few subjects. This study aimed to evaluate the effect of hydrocortisone administration on the outcomes of patients who experienced cardiac arrest. We investigated the survival discharge rates and the length of hospital stay from cardiac arrest to discharge, stratified by use of hydrocortisone, using a Japanese health-insurance claims dataset that covers approximately 2% of the Japanese population. The study included the data of 2233 subjects who experienced either in-hospital or out-of-hospital cardiac arrest between January 2005 and May 2014. These patients were divided into two groups, based on the administration of hydrocortisone. We adjusted the baseline characteristics, medical treatment, and drug administration data of the two groups using propensity scores obtained via the inverse probability of treatment weighted method. The hydrocortisone group had a significantly higher survival discharge rate (13/61 [21.1%] vs. 240/2172 [11.0%], adjusted odds ratio: 4.2, 95% CI: 1.60–10.98, p = 0.004). In addition, the administration of hydrocortisone was independent predictor of survival to discharge (hazard ratio: 4.6, p < 0.001). The results demonstrate a correlation between hydrocortisone administration and the high rates of survival to discharge. Nature Publishing Group UK 2017-12-20 /pmc/articles/PMC5738407/ /pubmed/29263333 http://dx.doi.org/10.1038/s41598-017-17686-3 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Niimura, Takahiro
Zamami, Yoshito
Koyama, Toshihiro
Izawa-Ishizawa, Yuki
Miyake, Masashi
Koga, Tadashi
Harada, Keisaku
Ohshima, Ayako
Imai, Toru
Kondo, Yutaka
Imanishi, Masaki
Takechi, Kenshi
Fukushima, Keijo
Horinouchi, Yuya
Ikeda, Yasumasa
Fujino, Hiromichi
Tsuchiya, Koichiro
Tamaki, Toshiaki
Hinotsu, Shiro
Kano, Mitsunobu R.
Ishizawa, Keisuke
Hydrocortisone administration was associated with improved survival in Japanese patients with cardiac arrest
title Hydrocortisone administration was associated with improved survival in Japanese patients with cardiac arrest
title_full Hydrocortisone administration was associated with improved survival in Japanese patients with cardiac arrest
title_fullStr Hydrocortisone administration was associated with improved survival in Japanese patients with cardiac arrest
title_full_unstemmed Hydrocortisone administration was associated with improved survival in Japanese patients with cardiac arrest
title_short Hydrocortisone administration was associated with improved survival in Japanese patients with cardiac arrest
title_sort hydrocortisone administration was associated with improved survival in japanese patients with cardiac arrest
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738407/
https://www.ncbi.nlm.nih.gov/pubmed/29263333
http://dx.doi.org/10.1038/s41598-017-17686-3
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