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Identification and characterization of the structure–activity relationships involved in UGT1A1 inhibition by anthraquinone and dianthrone constituents of Polygonum multiflorum

The adverse effects of Polygonum (P.) multiflorum, including abnormal bilirubin metabolism, are a serious public health issue. As uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) is the only enzyme responsible for bilirubin metabolism, we investigated the inhibitory effect of a P. mult...

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Detalles Bibliográficos
Autores principales:	Wang, Qi, Wang, Yadan, Li, Yong, Wen, Binyu, Dai, Zhong, Ma, Shuangcheng, Zhang, Yujie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738440/ https://www.ncbi.nlm.nih.gov/pubmed/29263357 http://dx.doi.org/10.1038/s41598-017-18231-y

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