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Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kα and PIP(3) Signaling

Cellular pathways controlling chemotaxis, growth, survival, and oncogenesis are activated by receptor tyrosine kinases and small G-proteins of the Ras superfamily that stimulate specific isoforms of phosphatidylinositol-3-kinase (PI3K). These PI3K lipid kinases phosphorylate the constitutive lipid p...

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Detalles Bibliográficos
Autores principales:	Buckles, Thomas C., Ziemba, Brian P., Masson, Glenn R., Williams, Roger L., Falke, Joseph J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Biophysical Society 2017
Materias:	Membranes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738497/ https://www.ncbi.nlm.nih.gov/pubmed/29211993 http://dx.doi.org/10.1016/j.bpj.2017.09.018

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