Possible Effect of Concomitant Prokinetics and Herbal Medicines against Nausea in Patients Taking Lubiprostone

BACKGROUND AND AIM: Lubiprostone is a novel laxative that sometimes causes nausea, but preventive strategies remain unconfirmed. METHODS: We retrospectively chose 126 patients prescribed lubiprostone from 2013 to 2016. Medical records were reviewed to clarify whether nausea developed after administr...

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Autores principales: Yamamoto, Takatsugu, Osumi, Shun, Yanagisawa, Daisuke, Yamato, Hiroshi, Aoyagi, Hitoshi, Isono, Akari, Abe, Koichiro, Kita, Hiroto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738584/
https://www.ncbi.nlm.nih.gov/pubmed/29362710
http://dx.doi.org/10.1155/2017/3762179
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author Yamamoto, Takatsugu
Osumi, Shun
Yanagisawa, Daisuke
Yamato, Hiroshi
Aoyagi, Hitoshi
Isono, Akari
Abe, Koichiro
Kita, Hiroto
author_facet Yamamoto, Takatsugu
Osumi, Shun
Yanagisawa, Daisuke
Yamato, Hiroshi
Aoyagi, Hitoshi
Isono, Akari
Abe, Koichiro
Kita, Hiroto
author_sort Yamamoto, Takatsugu
collection PubMed
description BACKGROUND AND AIM: Lubiprostone is a novel laxative that sometimes causes nausea, but preventive strategies remain unconfirmed. METHODS: We retrospectively chose 126 patients prescribed lubiprostone from 2013 to 2016. Medical records were reviewed to clarify whether nausea developed after administration of the drug. Background characteristics, including concomitant medicines, were also reviewed. RESULTS: The most common adverse symptom was diarrhea (23.8%). Nausea occurred in 16 patients (12.7%). Patients taking either prokinetics or herbal medicines or both were unlikely to develop nausea (p = 0.007). CONCLUSIONS: Concomitant prokinetics and/or herbal medicines may help alleviate lubiprostone-induced nausea.
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spelling pubmed-57385842018-01-23 Possible Effect of Concomitant Prokinetics and Herbal Medicines against Nausea in Patients Taking Lubiprostone Yamamoto, Takatsugu Osumi, Shun Yanagisawa, Daisuke Yamato, Hiroshi Aoyagi, Hitoshi Isono, Akari Abe, Koichiro Kita, Hiroto Biomed Res Int Research Article BACKGROUND AND AIM: Lubiprostone is a novel laxative that sometimes causes nausea, but preventive strategies remain unconfirmed. METHODS: We retrospectively chose 126 patients prescribed lubiprostone from 2013 to 2016. Medical records were reviewed to clarify whether nausea developed after administration of the drug. Background characteristics, including concomitant medicines, were also reviewed. RESULTS: The most common adverse symptom was diarrhea (23.8%). Nausea occurred in 16 patients (12.7%). Patients taking either prokinetics or herbal medicines or both were unlikely to develop nausea (p = 0.007). CONCLUSIONS: Concomitant prokinetics and/or herbal medicines may help alleviate lubiprostone-induced nausea. Hindawi 2017 2017-12-07 /pmc/articles/PMC5738584/ /pubmed/29362710 http://dx.doi.org/10.1155/2017/3762179 Text en Copyright © 2017 Takatsugu Yamamoto et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yamamoto, Takatsugu
Osumi, Shun
Yanagisawa, Daisuke
Yamato, Hiroshi
Aoyagi, Hitoshi
Isono, Akari
Abe, Koichiro
Kita, Hiroto
Possible Effect of Concomitant Prokinetics and Herbal Medicines against Nausea in Patients Taking Lubiprostone
title Possible Effect of Concomitant Prokinetics and Herbal Medicines against Nausea in Patients Taking Lubiprostone
title_full Possible Effect of Concomitant Prokinetics and Herbal Medicines against Nausea in Patients Taking Lubiprostone
title_fullStr Possible Effect of Concomitant Prokinetics and Herbal Medicines against Nausea in Patients Taking Lubiprostone
title_full_unstemmed Possible Effect of Concomitant Prokinetics and Herbal Medicines against Nausea in Patients Taking Lubiprostone
title_short Possible Effect of Concomitant Prokinetics and Herbal Medicines against Nausea in Patients Taking Lubiprostone
title_sort possible effect of concomitant prokinetics and herbal medicines against nausea in patients taking lubiprostone
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738584/
https://www.ncbi.nlm.nih.gov/pubmed/29362710
http://dx.doi.org/10.1155/2017/3762179
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