Cargando…

Targeting microRNA/UHRF1 pathways as a novel strategy for cancer therapy

Ubiquitin-like containing plant homeodomain and RING finger domains 1 (UHRF1) is an anti-apoptotic protein involved in the silencing of several tumor suppressor genes (TSGs) through epigenetic modifications including DNA methylation and histone post-translational alterations, and also epigenetic-ind...

Descripción completa

Detalles Bibliográficos
Autores principales:	Choudhry, Hani, Zamzami, Mazin A., Omran, Ziad, Wu, Wei, Mousli, Marc, Bronner, Christian, Alhosin, Mahmoud
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738699/ https://www.ncbi.nlm.nih.gov/pubmed/29285183 http://dx.doi.org/10.3892/ol.2017.7290

Ejemplares similares

Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer
por: Alhosin, Mahmoud, et al.
Publicado: (2016)

Thymoquinone challenges UHRF1 to commit auto-ubiquitination: a key event for apoptosis induction in cancer cells
por: Ibrahim, Abdulkhaleg, et al.
Publicado: (2018)

Coordinated Dialogue between UHRF1 and DNMT1 to Ensure Faithful Inheritance of Methylated DNA Patterns
por: Bronner, Christian, et al.
Publicado: (2019)

Thymoquinone Is a Multitarget Single Epidrug That Inhibits the UHRF1 Protein Complex
por: Abdullah, Omeima, et al.
Publicado: (2021)

Interaction of the epigenetic integrator UHRF1 with the MYST domain of TIP60 inside the cell
por: Ashraf, Waseem, et al.
Publicado: (2017)

The epigenetic integrator UHRF1: on the road to become a universal biomarker for cancer
por: Ashraf, Waseem, et al.
Publicado: (2017)

Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties
por: Alhosin, Mahmoud, et al.
Publicado: (2011)

Natural and Synthetic Anticancer Epidrugs Targeting the Epigenetic Integrator UHRF1
por: Ashraf, Waseem, et al.
Publicado: (2023)

Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16(INK4A) re-expression related to UHRF1 and DNMT1 down-regulation
por: Krifa, Mounira, et al.
Publicado: (2013)

Thymoquinone and Difluoromethylornithine (DFMO) Synergistically Induce Apoptosis of Human Acute T Lymphoblastic Leukemia Jurkat Cells Through the Modulation of Epigenetic Pathways
por: Alhosin, Mahmoud, et al.
Publicado: (2020)

TIP60 governs the auto-ubiquitination of UHRF1 through USP7 dissociation from the UHRF1/USP7 complex
por: Ahmad, Tanveer, et al.
Publicado: (2021)

Targeting Post-Translational Modifications of the p73 Protein: A Promising Therapeutic Strategy for Tumors
por: Omran, Ziad, et al.
Publicado: (2021)

The microRNA signature of patients with sunitinib failure: regulation of UHRF1 pathways by microRNA-101 in renal cell carcinoma
por: Goto, Yusuke, et al.
Publicado: (2016)

Thymoquinone-Induced Reactivation of Tumor Suppressor Genes in Cancer Cells Involves Epigenetic Mechanisms
por: Qadi, Shahad A, et al.
Publicado: (2019)

Identification of Deregulated Signaling Pathways in Jurkat Cells in Response to a Novel Acylspermidine Analogue-N(4)-Erucoyl Spermidine
por: Razvi, Syed Shoeb, et al.
Publicado: (2018)

Regulation of UHRF1 by microRNA-9 modulates colorectal cancer cell proliferation and apoptosis
por: Zhu, Mingchen, et al.
Publicado: (2015)

Molecular profiling of epigenetic landscape of cancer cells during extracellular matrix detachment
por: Khan, Mohammad Imran, et al.
Publicado: (2021)

Gene Ontology and Expression Studies of Strigolactone Analogues on a Hepatocellular Carcinoma Cell Line
por: Hasan, Mohammed Nihal, et al.
Publicado: (2019)

Structural-Guided Identification of Small Molecule Inhibitor of UHRF1 Methyltransferase Activity
por: Awal, Md Abdul, et al.
Publicado: (2022)

Repurposing Disulfiram as an Anti-Obesity Drug: Treating and Preventing Obesity in High-Fat-Fed Rats
por: Omran, Ziad, et al.
Publicado: (2020)

Origin, Potential Therapeutic Targets and Treatment for Coronavirus Disease (COVID-19)
por: Nadeem, Muhammad Shahid, et al.
Publicado: (2020)

Role of hesperetin in LDL-receptor expression in hepatoma HepG2 cells
por: Bawazeer, Nora A., et al.
Publicado: (2016)

The Histone H3K27me3 Demethylases KDM6A/B Resist Anoikis and Transcriptionally Regulate Stemness-Related Genes
por: Shait Mohammed, Mohammed Razeeth, et al.
Publicado: (2022)

Untargeted Metabolomics Identifies Key Metabolic Pathways Altered by Thymoquinone in Leukemic Cancer Cells
por: AlGhamdi, Asma Ahmed, et al.
Publicado: (2020)

Experimental strategies for microRNA target identification
por: Thomson, Daniel W., et al.
Publicado: (2011)

Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia
por: Camps, Carme, et al.
Publicado: (2014)

POSSIBLE HYPOCHOLESTEROLEMIC EFFECT OF GINGER AND ROSEMARY OILS IN RATS
por: Eissa, Fatma A., et al.
Publicado: (2017)

Compound C, a Broad Kinase Inhibitor Alters Metabolic Fingerprinting of Extra Cellular Matrix Detached Cancer Cells
por: Shait Mohammed, Mohammed Razeeth, et al.
Publicado: (2021)

Assessment of circulating levels of microRNA-326, microRNA-424, and microRNA-511 as biomarkers for hepatocellular carcinoma in Egyptians
por: Youssef, Samar Samir, et al.
Publicado: (2022)

Computing disease-linked SOD1 mutations: deciphering protein stability and patient-phenotype relations
por: Kumar, Vijay, et al.
Publicado: (2017)

Carbon nanotube field-effect transistor (CNT-FET)-based biosensor for rapid detection of SARS-CoV-2 (COVID-19) surface spike protein S1
por: Zamzami, Mazin A., et al.
Publicado: (2022)

Prospects of IL-2 in Cancer Immunotherapy
por: Choudhry, Hani, et al.
Publicado: (2018)

Urolithin A and B Alter Cellular Metabolism and Induce Metabolites Associated with Apoptosis in Leukemic Cells
por: Alzahrani, Abdulaziz Musa, et al.
Publicado: (2021)

Direct Identification of Label-Free Gram-Negative Bacteria with Bioreceptor-Free Concentric Interdigitated Electrodes
por: Zamzami, Mazin, et al.
Publicado: (2023)

Comparative biochemical analysis of UHRF proteins reveals molecular mechanisms that uncouple UHRF2 from DNA methylation maintenance
por: Vaughan, Robert M, et al.
Publicado: (2018)

Circulating microRNA, secreted microRNA and exogenous plant microRNA
por: Zhang, Chenyu
Publicado: (2012)

UHRF1 Induces Metastasis in Thyroid Cancer
por: Kuang, Bo-Hua, et al.
Publicado: (2022)

The UHRF protein family in epigenetics, development, and carcinogenesis
por: UNOKI, Motoko, et al.
Publicado: (2022)

MicroRNA-based targeting of the Rho/ROCK pathway in therapeutic strategies after spinal cord injury
por: Kimura, Tetsu, et al.
Publicado: (2022)

MicroRNA-590 is an EMT-suppressive microRNA involved in the TGFβ signaling pathway
por: LIU, TIANMING, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_tc9tea26hv76069b66f5lbkci1