Evaluation of a Cryptococcal antigen Lateral Flow Assay in serum and cerebrospinal fluid for rapid diagnosis of cryptococcosis in Colombia

A Lateral Flow Assay to detect cryptococcal antigen (CrAg(®) LFA) in serum and cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective validation was performed. Sensitivity and specificity of the CrAg(®) LFA was 100%. High concordance (kappa index=1.0) between Cr...

Descripción completa

Detalles Bibliográficos
Autores principales: Cáceres, Diego H., Zuluaga, Alejandra, Tabares, Ángela M., Chiller, Tom, González, Ángel, Gómez, Beatriz L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto de Medicina Tropical 2017
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738761/
https://www.ncbi.nlm.nih.gov/pubmed/29267584
http://dx.doi.org/10.1590/S1678-9946201759076
Descripción
Sumario:A Lateral Flow Assay to detect cryptococcal antigen (CrAg(®) LFA) in serum and cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective validation was performed. Sensitivity and specificity of the CrAg(®) LFA was 100%. High concordance (kappa index=1.0) between Cryptococcal Antigen Latex Agglutination System (CALAS(®)) and CrAg(®) LFA was observed. CrAg(®) LFA showed higher analytical sensitivity for detecting low concentrations of cryptococcal antigen.

Ejemplares similares