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Molluscicidal effect of Euphorbia umbellata (Pax) Bruyns latex on Biomphalaria glabrata, Schistosoma mansoni host snail

Euphorbia umbellata (Pax) Bruyns is an easily cultivated shrub, with occurrence in the tropical regions of the American and African continents. Chemical studies have revealed that the latex of this plant is rich in terpene compounds, which are highly toxic to snails Biomphalaria glabrata (Basommatop...

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Autores principales: Pereira, Luciana Patrícia Lima Alves, Dias, Clarice Noleto, Miranda, Milena Valadar, Firmo, Wellyson da Cunha Araújo, Rosa, Carliane dos Santos, Santos, Priscila Freitas, Brito, Maria Cristiane Aranha, Araruna, Fernanda Oliveira Sousa, Araruna, Felipe Bastos, Silva-Souza, Nêuton, Coutinho, Denise Fernandes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto de Medicina Tropical 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738770/
https://www.ncbi.nlm.nih.gov/pubmed/29267593
http://dx.doi.org/10.1590/S1678-9946201759085
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author Pereira, Luciana Patrícia Lima Alves
Dias, Clarice Noleto
Miranda, Milena Valadar
Firmo, Wellyson da Cunha Araújo
Rosa, Carliane dos Santos
Santos, Priscila Freitas
Brito, Maria Cristiane Aranha
Araruna, Fernanda Oliveira Sousa
Araruna, Felipe Bastos
Silva-Souza, Nêuton
Coutinho, Denise Fernandes
author_facet Pereira, Luciana Patrícia Lima Alves
Dias, Clarice Noleto
Miranda, Milena Valadar
Firmo, Wellyson da Cunha Araújo
Rosa, Carliane dos Santos
Santos, Priscila Freitas
Brito, Maria Cristiane Aranha
Araruna, Fernanda Oliveira Sousa
Araruna, Felipe Bastos
Silva-Souza, Nêuton
Coutinho, Denise Fernandes
author_sort Pereira, Luciana Patrícia Lima Alves
collection PubMed
description Euphorbia umbellata (Pax) Bruyns is an easily cultivated shrub, with occurrence in the tropical regions of the American and African continents. Chemical studies have revealed that the latex of this plant is rich in terpene compounds, which are highly toxic to snails Biomphalaria glabrata (Basommatophora: Planorbidae). The aim of this study was to evaluate the chemical composition and molluscicidal activity of the latex produced by E. umbellata, as well as the safety of its application in aquatic environments. The concentration of latex that killed 90% of the exposed snails after 24 h exposure (LC(90)) was 3.69 mg/L. Toxicity bioassays using Danio rerio (zebrafish) revealed that these animals were less susceptible to latex than planorbids. However, it is important to perform other toxicity tests to ensure the feasibility of using latex to control populations of mollusks that contribute to schistosomiasis transmission. A phytochemical screening performed with the E. umbellata latex identified the triterpenoid and coumarin class. Further studies are warranted to isolate, identify, and test the active compounds of E. umbellata latex in B. glabrata.
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spelling pubmed-57387702018-01-02 Molluscicidal effect of Euphorbia umbellata (Pax) Bruyns latex on Biomphalaria glabrata, Schistosoma mansoni host snail Pereira, Luciana Patrícia Lima Alves Dias, Clarice Noleto Miranda, Milena Valadar Firmo, Wellyson da Cunha Araújo Rosa, Carliane dos Santos Santos, Priscila Freitas Brito, Maria Cristiane Aranha Araruna, Fernanda Oliveira Sousa Araruna, Felipe Bastos Silva-Souza, Nêuton Coutinho, Denise Fernandes Rev Inst Med Trop Sao Paulo Brief Communication Euphorbia umbellata (Pax) Bruyns is an easily cultivated shrub, with occurrence in the tropical regions of the American and African continents. Chemical studies have revealed that the latex of this plant is rich in terpene compounds, which are highly toxic to snails Biomphalaria glabrata (Basommatophora: Planorbidae). The aim of this study was to evaluate the chemical composition and molluscicidal activity of the latex produced by E. umbellata, as well as the safety of its application in aquatic environments. The concentration of latex that killed 90% of the exposed snails after 24 h exposure (LC(90)) was 3.69 mg/L. Toxicity bioassays using Danio rerio (zebrafish) revealed that these animals were less susceptible to latex than planorbids. However, it is important to perform other toxicity tests to ensure the feasibility of using latex to control populations of mollusks that contribute to schistosomiasis transmission. A phytochemical screening performed with the E. umbellata latex identified the triterpenoid and coumarin class. Further studies are warranted to isolate, identify, and test the active compounds of E. umbellata latex in B. glabrata. Instituto de Medicina Tropical 2017-12-21 /pmc/articles/PMC5738770/ /pubmed/29267593 http://dx.doi.org/10.1590/S1678-9946201759085 Text en https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Pereira, Luciana Patrícia Lima Alves
Dias, Clarice Noleto
Miranda, Milena Valadar
Firmo, Wellyson da Cunha Araújo
Rosa, Carliane dos Santos
Santos, Priscila Freitas
Brito, Maria Cristiane Aranha
Araruna, Fernanda Oliveira Sousa
Araruna, Felipe Bastos
Silva-Souza, Nêuton
Coutinho, Denise Fernandes
Molluscicidal effect of Euphorbia umbellata (Pax) Bruyns latex on Biomphalaria glabrata, Schistosoma mansoni host snail
title Molluscicidal effect of Euphorbia umbellata (Pax) Bruyns latex on Biomphalaria glabrata, Schistosoma mansoni host snail
title_full Molluscicidal effect of Euphorbia umbellata (Pax) Bruyns latex on Biomphalaria glabrata, Schistosoma mansoni host snail
title_fullStr Molluscicidal effect of Euphorbia umbellata (Pax) Bruyns latex on Biomphalaria glabrata, Schistosoma mansoni host snail
title_full_unstemmed Molluscicidal effect of Euphorbia umbellata (Pax) Bruyns latex on Biomphalaria glabrata, Schistosoma mansoni host snail
title_short Molluscicidal effect of Euphorbia umbellata (Pax) Bruyns latex on Biomphalaria glabrata, Schistosoma mansoni host snail
title_sort molluscicidal effect of euphorbia umbellata (pax) bruyns latex on biomphalaria glabrata, schistosoma mansoni host snail
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738770/
https://www.ncbi.nlm.nih.gov/pubmed/29267593
http://dx.doi.org/10.1590/S1678-9946201759085
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