HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

BACKGROUND: Heat shock protein 90 (HSP90) functions as a well-known onco-protein to regulate protein conformation, stability and degradation. Pyruvate kinase M2 (PKM2), a critical regulator of the metabolism, growth and metastasis of cancer cells, has been confirmed to be overexpressed in various hu...

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Detalles Bibliográficos
Autores principales: Xu, Qiuran, Tu, Jianfeng, Dou, Changwei, Zhang, Jun, Yang, Liu, Liu, Xin, Lei, Kefeng, Liu, Zhikui, Wang, Yufeng, Li, Lijie, Bao, Hangxing, Wang, Jiahui, Tu, Kangsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738801/
https://www.ncbi.nlm.nih.gov/pubmed/29262861
http://dx.doi.org/10.1186/s12943-017-0748-y

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