Systems-epigenomics inference of transcription factor activity implicates aryl-hydrocarbon-receptor inactivation as a key event in lung cancer development

BACKGROUND: Diverse molecular alterations associated with smoking in normal and precursor lung cancer cells have been reported, yet their role in lung cancer etiology remains unclear. A prominent example is hypomethylation of the aryl hydrocarbon-receptor repressor (AHRR) locus, which is observed in...

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Detalles Bibliográficos
Autores principales: Chen, Yuting, Widschwendter, Martin, Teschendorff, Andrew E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738803/
https://www.ncbi.nlm.nih.gov/pubmed/29262847
http://dx.doi.org/10.1186/s13059-017-1366-0

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