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Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes

BACKGROUND: Histones undergo extensive post-translational modifications and this epigenetic regulation plays an important role in modulating transcriptional programs capable of driving cancer progression. Acetylation of histone H3K18, associated with gene activation, is enhanced by P300 and opposed...

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Detalles Bibliográficos
Autores principales:	Damodaran, Shivashankar, Damaschke, Nathan, Gawdzik, Joseph, Yang, Bing, Shi, Cedric, Allen, Glenn O., Huang, Wei, Denu, John, Jarrard, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738829/ https://www.ncbi.nlm.nih.gov/pubmed/29262808 http://dx.doi.org/10.1186/s12885-017-3853-9

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