Cargando…

ShinyGPAS: interactive genomic prediction accuracy simulator based on deterministic formulas

BACKGROUND: Deterministic formulas for the accuracy of genomic predictions highlight the relationships among prediction accuracy and potential factors influencing prediction accuracy prior to performing computationally intensive cross-validation. Visualizing such deterministic formulas in an interac...

Descripción completa

Detalles Bibliográficos
Autor principal: Morota, Gota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738850/
https://www.ncbi.nlm.nih.gov/pubmed/29262775
http://dx.doi.org/10.1186/s12711-017-0368-4
_version_ 1783287774524211200
author Morota, Gota
author_facet Morota, Gota
author_sort Morota, Gota
collection PubMed
description BACKGROUND: Deterministic formulas for the accuracy of genomic predictions highlight the relationships among prediction accuracy and potential factors influencing prediction accuracy prior to performing computationally intensive cross-validation. Visualizing such deterministic formulas in an interactive manner may lead to a better understanding of how genetic factors control prediction accuracy. RESULTS: The software to simulate deterministic formulas for genomic prediction accuracy was implemented in R and encapsulated as a web-based Shiny application. Shiny genomic prediction accuracy simulator (ShinyGPAS) simulates various deterministic formulas and delivers dynamic scatter plots of prediction accuracy versus genetic factors impacting prediction accuracy, while requiring only mouse navigation in a web browser. ShinyGPAS is available at: https://chikudaisei.shinyapps.io/shinygpas/. CONCLUSION: ShinyGPAS is a shiny-based interactive genomic prediction accuracy simulator using deterministic formulas. It can be used for interactively exploring potential factors that influence prediction accuracy in genome-enabled prediction, simulating achievable prediction accuracy prior to genotyping individuals, or supporting in-class teaching. ShinyGPAS is open source software and it is hosted online as a freely available web-based resource with an intuitive graphical user interface.
format Online
Article
Text
id pubmed-5738850
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-57388502018-01-02 ShinyGPAS: interactive genomic prediction accuracy simulator based on deterministic formulas Morota, Gota Genet Sel Evol Software BACKGROUND: Deterministic formulas for the accuracy of genomic predictions highlight the relationships among prediction accuracy and potential factors influencing prediction accuracy prior to performing computationally intensive cross-validation. Visualizing such deterministic formulas in an interactive manner may lead to a better understanding of how genetic factors control prediction accuracy. RESULTS: The software to simulate deterministic formulas for genomic prediction accuracy was implemented in R and encapsulated as a web-based Shiny application. Shiny genomic prediction accuracy simulator (ShinyGPAS) simulates various deterministic formulas and delivers dynamic scatter plots of prediction accuracy versus genetic factors impacting prediction accuracy, while requiring only mouse navigation in a web browser. ShinyGPAS is available at: https://chikudaisei.shinyapps.io/shinygpas/. CONCLUSION: ShinyGPAS is a shiny-based interactive genomic prediction accuracy simulator using deterministic formulas. It can be used for interactively exploring potential factors that influence prediction accuracy in genome-enabled prediction, simulating achievable prediction accuracy prior to genotyping individuals, or supporting in-class teaching. ShinyGPAS is open source software and it is hosted online as a freely available web-based resource with an intuitive graphical user interface. BioMed Central 2017-12-20 /pmc/articles/PMC5738850/ /pubmed/29262775 http://dx.doi.org/10.1186/s12711-017-0368-4 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Software
Morota, Gota
ShinyGPAS: interactive genomic prediction accuracy simulator based on deterministic formulas
title ShinyGPAS: interactive genomic prediction accuracy simulator based on deterministic formulas
title_full ShinyGPAS: interactive genomic prediction accuracy simulator based on deterministic formulas
title_fullStr ShinyGPAS: interactive genomic prediction accuracy simulator based on deterministic formulas
title_full_unstemmed ShinyGPAS: interactive genomic prediction accuracy simulator based on deterministic formulas
title_short ShinyGPAS: interactive genomic prediction accuracy simulator based on deterministic formulas
title_sort shinygpas: interactive genomic prediction accuracy simulator based on deterministic formulas
topic Software
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738850/
https://www.ncbi.nlm.nih.gov/pubmed/29262775
http://dx.doi.org/10.1186/s12711-017-0368-4
work_keys_str_mv AT morotagota shinygpasinteractivegenomicpredictionaccuracysimulatorbasedondeterministicformulas