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ShinyGPAS: interactive genomic prediction accuracy simulator based on deterministic formulas
BACKGROUND: Deterministic formulas for the accuracy of genomic predictions highlight the relationships among prediction accuracy and potential factors influencing prediction accuracy prior to performing computationally intensive cross-validation. Visualizing such deterministic formulas in an interac...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738850/ https://www.ncbi.nlm.nih.gov/pubmed/29262775 http://dx.doi.org/10.1186/s12711-017-0368-4 |
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author | Morota, Gota |
author_facet | Morota, Gota |
author_sort | Morota, Gota |
collection | PubMed |
description | BACKGROUND: Deterministic formulas for the accuracy of genomic predictions highlight the relationships among prediction accuracy and potential factors influencing prediction accuracy prior to performing computationally intensive cross-validation. Visualizing such deterministic formulas in an interactive manner may lead to a better understanding of how genetic factors control prediction accuracy. RESULTS: The software to simulate deterministic formulas for genomic prediction accuracy was implemented in R and encapsulated as a web-based Shiny application. Shiny genomic prediction accuracy simulator (ShinyGPAS) simulates various deterministic formulas and delivers dynamic scatter plots of prediction accuracy versus genetic factors impacting prediction accuracy, while requiring only mouse navigation in a web browser. ShinyGPAS is available at: https://chikudaisei.shinyapps.io/shinygpas/. CONCLUSION: ShinyGPAS is a shiny-based interactive genomic prediction accuracy simulator using deterministic formulas. It can be used for interactively exploring potential factors that influence prediction accuracy in genome-enabled prediction, simulating achievable prediction accuracy prior to genotyping individuals, or supporting in-class teaching. ShinyGPAS is open source software and it is hosted online as a freely available web-based resource with an intuitive graphical user interface. |
format | Online Article Text |
id | pubmed-5738850 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-57388502018-01-02 ShinyGPAS: interactive genomic prediction accuracy simulator based on deterministic formulas Morota, Gota Genet Sel Evol Software BACKGROUND: Deterministic formulas for the accuracy of genomic predictions highlight the relationships among prediction accuracy and potential factors influencing prediction accuracy prior to performing computationally intensive cross-validation. Visualizing such deterministic formulas in an interactive manner may lead to a better understanding of how genetic factors control prediction accuracy. RESULTS: The software to simulate deterministic formulas for genomic prediction accuracy was implemented in R and encapsulated as a web-based Shiny application. Shiny genomic prediction accuracy simulator (ShinyGPAS) simulates various deterministic formulas and delivers dynamic scatter plots of prediction accuracy versus genetic factors impacting prediction accuracy, while requiring only mouse navigation in a web browser. ShinyGPAS is available at: https://chikudaisei.shinyapps.io/shinygpas/. CONCLUSION: ShinyGPAS is a shiny-based interactive genomic prediction accuracy simulator using deterministic formulas. It can be used for interactively exploring potential factors that influence prediction accuracy in genome-enabled prediction, simulating achievable prediction accuracy prior to genotyping individuals, or supporting in-class teaching. ShinyGPAS is open source software and it is hosted online as a freely available web-based resource with an intuitive graphical user interface. BioMed Central 2017-12-20 /pmc/articles/PMC5738850/ /pubmed/29262775 http://dx.doi.org/10.1186/s12711-017-0368-4 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Software Morota, Gota ShinyGPAS: interactive genomic prediction accuracy simulator based on deterministic formulas |
title | ShinyGPAS: interactive genomic prediction accuracy simulator based on deterministic formulas |
title_full | ShinyGPAS: interactive genomic prediction accuracy simulator based on deterministic formulas |
title_fullStr | ShinyGPAS: interactive genomic prediction accuracy simulator based on deterministic formulas |
title_full_unstemmed | ShinyGPAS: interactive genomic prediction accuracy simulator based on deterministic formulas |
title_short | ShinyGPAS: interactive genomic prediction accuracy simulator based on deterministic formulas |
title_sort | shinygpas: interactive genomic prediction accuracy simulator based on deterministic formulas |
topic | Software |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738850/ https://www.ncbi.nlm.nih.gov/pubmed/29262775 http://dx.doi.org/10.1186/s12711-017-0368-4 |
work_keys_str_mv | AT morotagota shinygpasinteractivegenomicpredictionaccuracysimulatorbasedondeterministicformulas |