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Addison disease and normocalcemic primary hyperparathyroidism in a dog with multiple endocrine neoplasia
A 12-year old dog with a 9-year history of primary adrenal insufficiency was referred to the service for hyporexia, muscle weakness, polyuria and polydipsia. Ultrasound examination showed an unresectable mass in the left adrenal gland, with local vascular invasion, which prompted the euthanasia of t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Faculty of Veterinary Medicine, University of Tripoli and Libyan Authority for Research, Science and Technology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738886/ https://www.ncbi.nlm.nih.gov/pubmed/29296592 http://dx.doi.org/10.4314/ovj.v7i4.8 |
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author | Arias, Elber Alberto Soler Castillo, Victor Alejandro Trigo, Roberto Hector |
author_facet | Arias, Elber Alberto Soler Castillo, Victor Alejandro Trigo, Roberto Hector |
author_sort | Arias, Elber Alberto Soler |
collection | PubMed |
description | A 12-year old dog with a 9-year history of primary adrenal insufficiency was referred to the service for hyporexia, muscle weakness, polyuria and polydipsia. Ultrasound examination showed an unresectable mass in the left adrenal gland, with local vascular invasion, which prompted the euthanasia of the animal. Additionally, necropsy revealed a nodular lesion in the right adrenal gland and enlargement of one of the four parathyroid glands. Parathyroid hormone levels were elevated, but ionized and total calcium levels were normal. Histopathology supported the diagnosis of parathyroid chief cell adenoma and bilateral pheochromocytoma. Immunohistochemical staining was positive for synaptophysin, and negative for Melan-A and calretinin, which confirmed the diagnosis of pheochromocytoma. This case highlights an unusual presentation of multiple endocrine neoplasias within the context of primary adrenal insufficiency and normocalcemic primary hyperparathyroidism. |
format | Online Article Text |
id | pubmed-5738886 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Faculty of Veterinary Medicine, University of Tripoli and Libyan Authority for Research, Science and Technology |
record_format | MEDLINE/PubMed |
spelling | pubmed-57388862018-01-02 Addison disease and normocalcemic primary hyperparathyroidism in a dog with multiple endocrine neoplasia Arias, Elber Alberto Soler Castillo, Victor Alejandro Trigo, Roberto Hector Open Vet J Case Report A 12-year old dog with a 9-year history of primary adrenal insufficiency was referred to the service for hyporexia, muscle weakness, polyuria and polydipsia. Ultrasound examination showed an unresectable mass in the left adrenal gland, with local vascular invasion, which prompted the euthanasia of the animal. Additionally, necropsy revealed a nodular lesion in the right adrenal gland and enlargement of one of the four parathyroid glands. Parathyroid hormone levels were elevated, but ionized and total calcium levels were normal. Histopathology supported the diagnosis of parathyroid chief cell adenoma and bilateral pheochromocytoma. Immunohistochemical staining was positive for synaptophysin, and negative for Melan-A and calretinin, which confirmed the diagnosis of pheochromocytoma. This case highlights an unusual presentation of multiple endocrine neoplasias within the context of primary adrenal insufficiency and normocalcemic primary hyperparathyroidism. Faculty of Veterinary Medicine, University of Tripoli and Libyan Authority for Research, Science and Technology 2017 2017-12-05 /pmc/articles/PMC5738886/ /pubmed/29296592 http://dx.doi.org/10.4314/ovj.v7i4.8 Text en Copyright: © Open Veterinary Journal http://creativecommons.org/licenses/by-nc-sa/4.0 Open Veterinary Journal is licensed under a Creative Commons Attribution 4.0 International License. |
spellingShingle | Case Report Arias, Elber Alberto Soler Castillo, Victor Alejandro Trigo, Roberto Hector Addison disease and normocalcemic primary hyperparathyroidism in a dog with multiple endocrine neoplasia |
title | Addison disease and normocalcemic primary hyperparathyroidism in a dog with multiple endocrine neoplasia |
title_full | Addison disease and normocalcemic primary hyperparathyroidism in a dog with multiple endocrine neoplasia |
title_fullStr | Addison disease and normocalcemic primary hyperparathyroidism in a dog with multiple endocrine neoplasia |
title_full_unstemmed | Addison disease and normocalcemic primary hyperparathyroidism in a dog with multiple endocrine neoplasia |
title_short | Addison disease and normocalcemic primary hyperparathyroidism in a dog with multiple endocrine neoplasia |
title_sort | addison disease and normocalcemic primary hyperparathyroidism in a dog with multiple endocrine neoplasia |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738886/ https://www.ncbi.nlm.nih.gov/pubmed/29296592 http://dx.doi.org/10.4314/ovj.v7i4.8 |
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