Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment

BACKGROUND: Tumor-associated macrophages (TAMs) are abundant in gliomas and immunosuppressive TAMs are a barrier to emerging immunotherapies. It is unknown to what extent macrophages derived from peripheral blood adopt the phenotype of brain-resident microglia in pre-treatment gliomas. The relative...

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Detalles Bibliográficos
Autores principales: Müller, Sören, Kohanbash, Gary, Liu, S. John, Alvarado, Beatriz, Carrera, Diego, Bhaduri, Aparna, Watchmaker, Payal B., Yagnik, Garima, Di Lullo, Elizabeth, Malatesta, Martina, Amankulor, Nduka M., Kriegstein, Arnold R., Lim, Daniel A., Aghi, Manish, Okada, Hideho, Diaz, Aaron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738907/
https://www.ncbi.nlm.nih.gov/pubmed/29262845
http://dx.doi.org/10.1186/s13059-017-1362-4

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