Disease Severity and Effective Parasite Multiplication Rate in Falciparum Malaria

Patients presenting with severe falciparum malaria in a Bangladeshi tertiary hospital had higher total parasite burden, estimated by parasitemia and plasma PfHRP2, than uncomplicated malaria patients despite shorter fever duration. This suggests that higher parasite multiplication rates (PMR) contri...

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Detalles Bibliográficos
Autores principales: Kingston, Hugh W, Ghose, Aniruddha, Plewes, Katherine, Ishioka, Haruhiko, Leopold, Stije J, Maude, Richard J, Paul, Sanjib, Intharabut, Benjamas, Silamut, Kamorat, Woodrow, Charles, Day, Nicholas P J, Chotivanich, Kesinee, Anstey, Nicholas M, Hossain, Amir, White, Nicholas J, Dondorp, Arjen M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739038/
https://www.ncbi.nlm.nih.gov/pubmed/29302604
http://dx.doi.org/10.1093/ofid/ofx169
Descripción
Sumario:Patients presenting with severe falciparum malaria in a Bangladeshi tertiary hospital had higher total parasite burden, estimated by parasitemia and plasma PfHRP2, than uncomplicated malaria patients despite shorter fever duration. This suggests that higher parasite multiplication rates (PMR) contribute to causing the higher biomass found in severe disease. Compared with patients without a history of previous malaria, patients with previous malaria carried a lower parasite biomass with similar fever duration at presentation, suggesting that host immunity reduces the PMR.

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