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Disease Severity and Effective Parasite Multiplication Rate in Falciparum Malaria
Patients presenting with severe falciparum malaria in a Bangladeshi tertiary hospital had higher total parasite burden, estimated by parasitemia and plasma PfHRP2, than uncomplicated malaria patients despite shorter fever duration. This suggests that higher parasite multiplication rates (PMR) contri...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739038/ https://www.ncbi.nlm.nih.gov/pubmed/29302604 http://dx.doi.org/10.1093/ofid/ofx169 |
| _version_ | 1783287799977345024 |
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| author | Kingston, Hugh W Ghose, Aniruddha Plewes, Katherine Ishioka, Haruhiko Leopold, Stije J Maude, Richard J Paul, Sanjib Intharabut, Benjamas Silamut, Kamorat Woodrow, Charles Day, Nicholas P J Chotivanich, Kesinee Anstey, Nicholas M Hossain, Amir White, Nicholas J Dondorp, Arjen M |
| author_facet | Kingston, Hugh W Ghose, Aniruddha Plewes, Katherine Ishioka, Haruhiko Leopold, Stije J Maude, Richard J Paul, Sanjib Intharabut, Benjamas Silamut, Kamorat Woodrow, Charles Day, Nicholas P J Chotivanich, Kesinee Anstey, Nicholas M Hossain, Amir White, Nicholas J Dondorp, Arjen M |
| author_sort | Kingston, Hugh W |
| collection | PubMed |
| description | Patients presenting with severe falciparum malaria in a Bangladeshi tertiary hospital had higher total parasite burden, estimated by parasitemia and plasma PfHRP2, than uncomplicated malaria patients despite shorter fever duration. This suggests that higher parasite multiplication rates (PMR) contribute to causing the higher biomass found in severe disease. Compared with patients without a history of previous malaria, patients with previous malaria carried a lower parasite biomass with similar fever duration at presentation, suggesting that host immunity reduces the PMR. |
| format | Online Article Text |
| id | pubmed-5739038 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-57390382018-01-04 Disease Severity and Effective Parasite Multiplication Rate in Falciparum Malaria Kingston, Hugh W Ghose, Aniruddha Plewes, Katherine Ishioka, Haruhiko Leopold, Stije J Maude, Richard J Paul, Sanjib Intharabut, Benjamas Silamut, Kamorat Woodrow, Charles Day, Nicholas P J Chotivanich, Kesinee Anstey, Nicholas M Hossain, Amir White, Nicholas J Dondorp, Arjen M Open Forum Infect Dis Brief Report Patients presenting with severe falciparum malaria in a Bangladeshi tertiary hospital had higher total parasite burden, estimated by parasitemia and plasma PfHRP2, than uncomplicated malaria patients despite shorter fever duration. This suggests that higher parasite multiplication rates (PMR) contribute to causing the higher biomass found in severe disease. Compared with patients without a history of previous malaria, patients with previous malaria carried a lower parasite biomass with similar fever duration at presentation, suggesting that host immunity reduces the PMR. Oxford University Press 2017-12-20 /pmc/articles/PMC5739038/ /pubmed/29302604 http://dx.doi.org/10.1093/ofid/ofx169 Text en © The Author(s) 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Brief Report Kingston, Hugh W Ghose, Aniruddha Plewes, Katherine Ishioka, Haruhiko Leopold, Stije J Maude, Richard J Paul, Sanjib Intharabut, Benjamas Silamut, Kamorat Woodrow, Charles Day, Nicholas P J Chotivanich, Kesinee Anstey, Nicholas M Hossain, Amir White, Nicholas J Dondorp, Arjen M Disease Severity and Effective Parasite Multiplication Rate in Falciparum Malaria |
| title | Disease Severity and Effective Parasite Multiplication Rate in Falciparum Malaria |
| title_full | Disease Severity and Effective Parasite Multiplication Rate in Falciparum Malaria |
| title_fullStr | Disease Severity and Effective Parasite Multiplication Rate in Falciparum Malaria |
| title_full_unstemmed | Disease Severity and Effective Parasite Multiplication Rate in Falciparum Malaria |
| title_short | Disease Severity and Effective Parasite Multiplication Rate in Falciparum Malaria |
| title_sort | disease severity and effective parasite multiplication rate in falciparum malaria |
| topic | Brief Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739038/ https://www.ncbi.nlm.nih.gov/pubmed/29302604 http://dx.doi.org/10.1093/ofid/ofx169 |
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