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First-in-Man Demonstration of Direct Endothelin-Mediated Natriuresis and Diuresis

Endothelin (ET) receptor antagonists are potentially novel therapeutic agents in chronic kidney disease and resistant hypertension, but their use is complicated by sodium and water retention. In animal studies, this side effect arises from ET(B) receptor blockade in the renal tubule. Previous attemp...

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Detalles Bibliográficos
Autores principales:	Hunter, Robert W., Moorhouse, Rebecca, Farrah, Tariq E., MacIntyre, Iain M., Asai, Takae, Gallacher, Peter J., Kerr, Debbie, Melville, Vanessa, Czopek, Alicja, Morrison, Emma E., Ivy, Jess R., Dear, James W., Bailey, Matthew A., Goddard, Jane, Webb, David J., Dhaun, Neeraj
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott, Williams & Wilkins 2017
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739104/ https://www.ncbi.nlm.nih.gov/pubmed/28507171 http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.08832

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