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Perioperative Rehabilitation in Operable Lung Cancer Patients (PROLUCA): A Feasibility Study

Introduction. Surgical resection in patients with non–small cell lung cancer (NSCLC) may be associated with significant morbidity, functional limitations, and decreased quality of life. Objectives. The safety and feasibility of a preoperative and early postoperative rehabilitation program in patient...

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Autores principales: Sommer, Maja S., Trier, Karen, Vibe-Petersen, Jette, Missel, Malene, Christensen, Merete, Larsen, Klaus R., Langer, Seppo W., Hendriksen, Carsten, Clementsen, Paul Frost, Pedersen, Jesper H., Langberg, Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739160/
https://www.ncbi.nlm.nih.gov/pubmed/27151595
http://dx.doi.org/10.1177/1534735416635741
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author Sommer, Maja S.
Trier, Karen
Vibe-Petersen, Jette
Missel, Malene
Christensen, Merete
Larsen, Klaus R.
Langer, Seppo W.
Hendriksen, Carsten
Clementsen, Paul Frost
Pedersen, Jesper H.
Langberg, Henning
author_facet Sommer, Maja S.
Trier, Karen
Vibe-Petersen, Jette
Missel, Malene
Christensen, Merete
Larsen, Klaus R.
Langer, Seppo W.
Hendriksen, Carsten
Clementsen, Paul Frost
Pedersen, Jesper H.
Langberg, Henning
author_sort Sommer, Maja S.
collection PubMed
description Introduction. Surgical resection in patients with non–small cell lung cancer (NSCLC) may be associated with significant morbidity, functional limitations, and decreased quality of life. Objectives. The safety and feasibility of a preoperative and early postoperative rehabilitation program in patients operated for NSCLC was determined in a nonhospital setting, with focus on high-intensity interval exercise. Methods. Forty patients with biopsy-proven NSCLC stages I to IIIa referred for surgical resection at the Department of Cardiothoracic Surgery RT, Rigshospitalet, University of Copenhagen, were randomly assigned to 1 of 4 groups (3 intervention groups and 1 control group). The preoperative intervention consisted of a home-based exercise program, while the postoperative exercise program comprised a supervised group exercise program involving resistance and high-intensity interval cardiorespiratory exercise 2 hours weekly for 12 weeks combined with individual counseling. The study endpoints were inclusion rate, adherence, and number of adverse events. Results. Forty patients (of 124 screened; 32%) were included and randomized into the 4 groups. The postoperative exercise was completed by 73% of the patients randomized to this intervention. No adverse events were observed, indicating that the early postoperative exercise program is safe. The preoperative home-based exercise program was not feasible due to interfering diagnostic procedures and fast-track surgery that left only 1 to 2 weeks between diagnosis and surgery. Conclusion. The early postoperative exercise program for patients with NSCLC was safe and feasible, but in a fast-track set up, a preoperative home-based exercise program was not feasible for this population.
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spelling pubmed-57391602018-01-10 Perioperative Rehabilitation in Operable Lung Cancer Patients (PROLUCA): A Feasibility Study Sommer, Maja S. Trier, Karen Vibe-Petersen, Jette Missel, Malene Christensen, Merete Larsen, Klaus R. Langer, Seppo W. Hendriksen, Carsten Clementsen, Paul Frost Pedersen, Jesper H. Langberg, Henning Integr Cancer Ther Research Articles Introduction. Surgical resection in patients with non–small cell lung cancer (NSCLC) may be associated with significant morbidity, functional limitations, and decreased quality of life. Objectives. The safety and feasibility of a preoperative and early postoperative rehabilitation program in patients operated for NSCLC was determined in a nonhospital setting, with focus on high-intensity interval exercise. Methods. Forty patients with biopsy-proven NSCLC stages I to IIIa referred for surgical resection at the Department of Cardiothoracic Surgery RT, Rigshospitalet, University of Copenhagen, were randomly assigned to 1 of 4 groups (3 intervention groups and 1 control group). The preoperative intervention consisted of a home-based exercise program, while the postoperative exercise program comprised a supervised group exercise program involving resistance and high-intensity interval cardiorespiratory exercise 2 hours weekly for 12 weeks combined with individual counseling. The study endpoints were inclusion rate, adherence, and number of adverse events. Results. Forty patients (of 124 screened; 32%) were included and randomized into the 4 groups. The postoperative exercise was completed by 73% of the patients randomized to this intervention. No adverse events were observed, indicating that the early postoperative exercise program is safe. The preoperative home-based exercise program was not feasible due to interfering diagnostic procedures and fast-track surgery that left only 1 to 2 weeks between diagnosis and surgery. Conclusion. The early postoperative exercise program for patients with NSCLC was safe and feasible, but in a fast-track set up, a preoperative home-based exercise program was not feasible for this population. SAGE Publications 2016-05-04 2016-12 /pmc/articles/PMC5739160/ /pubmed/27151595 http://dx.doi.org/10.1177/1534735416635741 Text en © The Author(s) 2016 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research Articles
Sommer, Maja S.
Trier, Karen
Vibe-Petersen, Jette
Missel, Malene
Christensen, Merete
Larsen, Klaus R.
Langer, Seppo W.
Hendriksen, Carsten
Clementsen, Paul Frost
Pedersen, Jesper H.
Langberg, Henning
Perioperative Rehabilitation in Operable Lung Cancer Patients (PROLUCA): A Feasibility Study
title Perioperative Rehabilitation in Operable Lung Cancer Patients (PROLUCA): A Feasibility Study
title_full Perioperative Rehabilitation in Operable Lung Cancer Patients (PROLUCA): A Feasibility Study
title_fullStr Perioperative Rehabilitation in Operable Lung Cancer Patients (PROLUCA): A Feasibility Study
title_full_unstemmed Perioperative Rehabilitation in Operable Lung Cancer Patients (PROLUCA): A Feasibility Study
title_short Perioperative Rehabilitation in Operable Lung Cancer Patients (PROLUCA): A Feasibility Study
title_sort perioperative rehabilitation in operable lung cancer patients (proluca): a feasibility study
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739160/
https://www.ncbi.nlm.nih.gov/pubmed/27151595
http://dx.doi.org/10.1177/1534735416635741
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