Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis

Son of Sevenless 1 (SOS1) is a dual guanine nucleotide exchange factor (GEF) that activates the small GTPases RAC and RAS. Although the molecular mechanisms of RAS GEF catalysis have been unveiled, how SOS1 acquires RAC GEF activity and what is the physio-pathological relevance of this activity is m...

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Detalles Bibliográficos
Autores principales: Gerboth, S, Frittoli, E, Palamidessi, A, Baltanas, F C, Salek, M, Rappsilber, J, Giuliani, C, Troglio, F, Rolland, Y, Pruneri, G, Kreutmair, S, Pallavicini, I, Zobel, M, Cinquanta, M, Minucci, S, Gomez, C, Santos, E, Illert, A L, Scita, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739283/
https://www.ncbi.nlm.nih.gov/pubmed/28819285
http://dx.doi.org/10.1038/leu.2017.267

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