Lipid metabolic perturbation is an early-onset phenotype in adult spinster mutants: a Drosophila model for lysosomal storage disorders

Intracellular accumulation of lipids and swollen dysfunctional lysosomes are linked to several neurodegenerative diseases, including lysosomal storage disorders (LSD). Detailed characterization of lipid metabolic changes in relation to the onset and progression of neurodegeneration is currently miss...

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Detalles Bibliográficos
Autores principales: Hebbar, Sarita, Khandelwal, Avinash, Jayashree, R., Hindle, Samantha J., Chiang, Yin Ning, Yew, Joanne Y., Sweeney, Sean T., Schwudke, Dominik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739291/
https://www.ncbi.nlm.nih.gov/pubmed/29046397
http://dx.doi.org/10.1091/mbc.E16-09-0674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739291/
https://www.ncbi.nlm.nih.gov/pubmed/29046397
http://dx.doi.org/10.1091/mbc.E16-09-0674

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