Phosphorylation of multiple sites within an acidic region of Alcadein α is required for kinesin-1 association and Golgi exit of Alcadein α cargo

Alcadein α (Alcα) is a major cargo of kinesin-1 that is subjected to anterograde transport in neuronal axons. Two tryptophan- and aspartic acid-containing (WD) motifs located in its cytoplasmic domain directly bind the tetratricopeptide repeat (TPR) motifs of the kinesin light chain (KLC), which act...

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Detalles Bibliográficos
Autores principales: Sobu, Yuriko, Furukori, Keiko, Chiba, Kyoko, Nairn, Angus C., Kinjo, Masataka, Hata, Saori, Suzuki, Toshiharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739299/
https://www.ncbi.nlm.nih.gov/pubmed/29093024
http://dx.doi.org/10.1091/mbc.E17-05-0301

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