Cardiac-specific ablation of the E3 ubiquitin ligase Mdm2 leads to oxidative stress, broad mitochondrial deficiency and early death

The maintenance of normal heart function requires proper control of protein turnover. The ubiquitin-proteasome system is a principal regulator of protein degradation. Mdm2 is the main E3 ubiquitin ligase for p53 in mitotic cells thereby regulating cellular growth, DNA repair, oxidative stress and ap...

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Detalles Bibliográficos
Autores principales: Hauck, Ludger, Stanley-Hasnain, Shanna, Fung, Amelia, Grothe, Daniela, Rao, Vivek, Mak, Tak W., Billia, Filio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739440/
https://www.ncbi.nlm.nih.gov/pubmed/29267372
http://dx.doi.org/10.1371/journal.pone.0189861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739440/
https://www.ncbi.nlm.nih.gov/pubmed/29267372
http://dx.doi.org/10.1371/journal.pone.0189861

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