Discovery and evaluation of triple inhibitors of VEGFR-2, TIE-2 and EphB4 as anti-angiogenic and anti-cancer agents

Receptor tyrosine kinases (RTKs), especially VEGFR-2, TIE-2, and EphB4, play a crucial role in both angiogenesis and tumorigenesis. Moreover, complexity and heterogeneity of angiogenesis make it difficult to treat such pathological traits with single-target agents. Herein, we developed two classes o...

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Detalles Bibliográficos
Autores principales: Zhang, Lin, Shan, Yuanyuan, Ji, Xingyue, Zhu, Mengyuan, Li, Chuansheng, Sun, Ying, Si, Ru, Pan, Xiaoyan, Wang, Jinfeng, Ma, Weina, Dai, Bingling, Wang, Binghe, Zhang, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739597/
https://www.ncbi.nlm.nih.gov/pubmed/29285210
http://dx.doi.org/10.18632/oncotarget.20065

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