Cargando…

A c-Jun N-terminal kinase inhibitor, JNK-IN-8, sensitizes triple negative breast cancer cells to lapatinib

Triple negative breast cancers (TNBC) have poor prognosis compared to other breast cancer subtypes and represent 15-20% of breast cancers diagnosed. Unique targets and new molecularly-targeted therapies are urgently needed for this subtype. Despite high expression of Epidermal Growth Factor Receptor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ebelt, Nancy D., Kaoud, Tamer S., Edupuganti, Ramakrishna, Van Ravenstein, Sabrina, Dalby, Kevin N., Van Den Berg, Carla L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739608/ https://www.ncbi.nlm.nih.gov/pubmed/29285221 http://dx.doi.org/10.18632/oncotarget.20581

Ejemplares similares

c-Jun N-terminal kinase 2 prevents luminal cell commitment in normal mammary glands and tumors by inhibiting p53/Notch1 and breast cancer gene 1 expression
por: Cantrell, Michael A., et al.
Publicado: (2015)

Alarmins and c-Jun N-Terminal Kinase (JNK) Signaling in Neuroinflammation
por: Anfinogenova, Nina D., et al.
Publicado: (2020)

The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases
por: Chen, Jing, et al.
Publicado: (2021)

Stressor-Like Effects of c-Jun N-Terminal Kinase (JNK) Inhibition
por: Clarke, Melanie, et al.
Publicado: (2012)

Molecular docking of C-Jun-N-Terminal Kinase (Jnk) with amino-pyrimidine derivatives
por: Meenakumari, Krishnamoorthy, et al.
Publicado: (2020)

Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes
por: Yung, Justin Hou Ming, et al.
Publicado: (2020)

Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo
por: Kaoud, Tamer S., et al.
Publicado: (2019)

Activation of c-Jun N-Terminal Kinase (JNK) during Mitosis in Retinal Progenitor Cells
por: Ribas, Vinicius Toledo, et al.
Publicado: (2012)

C-Jun N-terminal kinase (JNK) isoforms play differing roles in otitis media
por: Yao, William, et al.
Publicado: (2014)

c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer’s Disease
por: Yarza, Ramon, et al.
Publicado: (2016)

c-JUN n-Terminal Kinase (JNK) Signaling in Autosomal Dominant Polycystic Kidney Disease
por: Smith, Abigail O., et al.
Publicado: (2022)

Novel Tryptanthrin Derivatives with Selectivity as c–Jun N–Terminal Kinase (JNK) 3 Inhibitors
por: Schepetkin, Igor A., et al.
Publicado: (2023)

Regulation of c-Jun NH(2)-terminal Kinase ( Jnk) Gene Expression during T Cell Activation
por: Weiss, Linda, et al.
Publicado: (2000)

C-Jun N-terminal kinase (JNK) pathway activation is essential for dental papilla cells polarization
por: Luo, Jiao, et al.
Publicado: (2021)

c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease
por: Smith, Abigail O., et al.
Publicado: (2021)

c-Jun NH(2)-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8(+) T Cell Activation
por: Conze, Dietrich, et al.
Publicado: (2002)

Non-kinase targeting of oncogenic c-Jun N-terminal kinase (JNK) signaling: the future of clinically viable cancer treatments
por: Latham, Sharissa L., et al.
Publicado: (2022)

A Predominant Role for Parenchymal c-Jun Amino Terminal Kinase (JNK) in the Regulation of Systemic Insulin Sensitivity
por: Vallerie, Sara N., et al.
Publicado: (2008)

JNK-Interacting Protein 3 Mediates the Retrograde Transport of Activated c-Jun N-Terminal Kinase and Lysosomes
por: Drerup, Catherine M., et al.
Publicado: (2013)

cJun N-terminal kinase (JNK) phosphorylation of serine 36 is critical for p66Shc activation
por: Khalid, Sana, et al.
Publicado: (2016)

Fish c-Jun N-Terminal Kinase (JNK) Pathway Is Involved in Bacterial MDP-Induced Intestinal Inflammation
por: Qu, Fufa, et al.
Publicado: (2020)

C-Jun Nh(2)-Terminal Kinase (Jnk)1 and Jnk2 Have Similar and Stage-Dependent Roles in Regulating T Cell Apoptosis and Proliferation
por: Sabapathy, Kanaga, et al.
Publicado: (2001)

c-Jun N-terminal kinase (JNK) cooperates with Gsk3β to regulate Dishevelled-mediated microtubule stability
por: Ciani, Lorenza, et al.
Publicado: (2007)

Correction: A Predominant Role for Parenchymal c-Jun Amino Terminal Kinase (JNK) in the Regulation of Systemic Insulin Sensitivity
por: Vallerie, Sara N., et al.
Publicado: (2009)

Endogenous c-Jun N-terminal kinase (JNK) activity marks the boundary between normal and malignant granulosa cells
por: Bildik, Gamze, et al.
Publicado: (2018)

The cJUN NH(2)-terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation
por: Girnius, Nomeda, et al.
Publicado: (2018)

Hepatitis C Virus Infection Increases c-Jun N-Terminal Kinase (JNK) Phosphorylation and Accentuates Hepatocyte Lipoapoptosis
por: Takaki, Hiroko, et al.
Publicado: (2017)

The cJUN NH(2)-terminal kinase (JNK) pathway contributes to mouse mammary gland remodeling during involution
por: Girnius, Nomeda, et al.
Publicado: (2018)

FK866 attenuates acute hepatic failure through c-jun-N-terminal kinase (JNK)-dependent autophagy
por: Guo, Enshuang, et al.
Publicado: (2017)

Activation of c-Jun N-terminal kinase (JNK) pathway by HSV-1 immediate early protein ICP0
por: Diao, Lirong, et al.
Publicado: (2005)

c-Jun N-terminal kinase 1 (JNK1) modulates oligodendrocyte progenitor cell architecture, proliferation and myelination
por: Lorenzati, Martina, et al.
Publicado: (2021)

A Novel c-Jun N-terminal Kinase (JNK)-binding Protein WDR62 Is Recruited to Stress Granules and Mediates a Nonclassical JNK Activation
por: Wasserman, Tanya, et al.
Publicado: (2010)

Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain
por: Mei, Xiao-Peng, et al.
Publicado: (2011)

Role of Jun amino-terminal kinase (JNK) in apoptosis of cavernosal tissue during acute phase after cavernosal nerve injury
por: Song, Won Hoon, et al.
Publicado: (2018)

Regulation of c-Jun N-Terminal Protein Kinase (JNK) Pathway in Apoptosis of Endothelial Outgrowth Cells Induced by Asymmetric Dimethylarginine
por: Zhang, Fu-Qing, et al.
Publicado: (2017)

c-Jun NH(2)-Terminal Kinase (JNK)1 and JNK2 Signaling Pathways Have Divergent Roles in CD8(+) T Cell–mediated Antiviral Immunity
por: Arbour, Nathalie, et al.
Publicado: (2002)

Short Arrestin-3-Derived Peptides Activate JNK3 in Cells
por: Perry-Hauser, Nicole A., et al.
Publicado: (2022)

The c-Jun N-terminal kinase (JNK) pathway is activated in human interstitial cystitis (IC) and rat protamine sulfate induced cystitis
por: Zhao, Jiang, et al.
Publicado: (2016)

Pharmacological c-Jun NH(2)-Terminal Kinase (JNK) Pathway Inhibition Reduces Severity of Spinal Muscular Atrophy Disease in Mice
por: Schellino, Roberta, et al.
Publicado: (2018)

JNK‐IN‐8, a c‐Jun N‐terminal kinase inhibitor, improves functional recovery through suppressing neuroinflammation in ischemic stroke
por: Zheng, Jianjian, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_kgqooe5jb2fp3c0os5dk6n9mqk