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Nuclear membrane-localised NOX4D generates pro-survival ROS in FLT3-ITD-expressing AML

Internal tandem duplication of the juxtamembrane domain of FMS-like tyrosine kinase 3 (FLT3-ITD) is the most prevalent genetic aberration present in 20-30% of acute myeloid leukaemia (AML) cases and is associated with a poor prognosis. FLT3-ITD expressing cells express elevated levels of NADPH oxida...

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Detalles Bibliográficos
Autores principales:	Moloney, Jennifer N., Jayavelu, Ashok Kumar, Stanicka, Joanna, Roche, Sarah L., O'Brien, Rebecca L., Scholl, Sebastian, Böhmer, Frank-D., Cotter, Thomas G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739649/ https://www.ncbi.nlm.nih.gov/pubmed/29285262 http://dx.doi.org/10.18632/oncotarget.22241

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