Renal oncocytoma characterized by the defective complex I of the respiratory chain boosts the synthesis of the ROS scavenger glutathione

Renal oncocytomas are rare benign tumors of the kidney and characterized by a deficient complex I (CI) enzyme activity of the oxidative phosphorylation (OXPHOS) system caused by mitochondrial DNA (mtDNA) mutations. Yet, little is known about the underlying molecular mechanisms and alterations of met...

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Detalles Bibliográficos
Autores principales: Kürschner, Gerrit, Zhang, Qingzhou, Clima, Rosanna, Xiao, Yi, Busch, Jonas Felix, Kilic, Ergin, Jung, Klaus, Berndt, Nikolaus, Bulik, Sascha, Holzhütter, Hermann-Georg, Gasparre, Giuseppe, Attimonelli, Marcella, Babu, Mohan, Meierhofer, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739687/
https://www.ncbi.nlm.nih.gov/pubmed/29285300
http://dx.doi.org/10.18632/oncotarget.22413

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