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Elevated pretreatment platelet distribution width and platelet count predict poor prognosis in nasopharyngeal carcinoma

BACKGROUND: Previous studies have demonstrated that platelets play a multifaceted role in cancer progression and metastasis. However, the value of platelet indices for predicting survival in nasopharyngeal carcinoma (NPC) patients remains unknown. The aim of this study was to evaluate the predictive...

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Autores principales: Xie, XueCheng, Zeng, XiaoChun, Cao, SuJuan, Hu, XiaoMao, Shi, QiaoJing, Li, Dan, Zhou, ShiYuan, Gu, Ping, Zhang, ZhongShan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739703/
https://www.ncbi.nlm.nih.gov/pubmed/29285316
http://dx.doi.org/10.18632/oncotarget.22528
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author Xie, XueCheng
Zeng, XiaoChun
Cao, SuJuan
Hu, XiaoMao
Shi, QiaoJing
Li, Dan
Zhou, ShiYuan
Gu, Ping
Zhang, ZhongShan
author_facet Xie, XueCheng
Zeng, XiaoChun
Cao, SuJuan
Hu, XiaoMao
Shi, QiaoJing
Li, Dan
Zhou, ShiYuan
Gu, Ping
Zhang, ZhongShan
author_sort Xie, XueCheng
collection PubMed
description BACKGROUND: Previous studies have demonstrated that platelets play a multifaceted role in cancer progression and metastasis. However, the value of platelet indices for predicting survival in nasopharyngeal carcinoma (NPC) patients remains unknown. The aim of this study was to evaluate the predictive significance of platelet indices in NPC cases. MATERIALS AND METHODS: A total of 168 patients who were diagnosed with NPC between January 2011 and June 2012 were recruited. The optimal cut-off values for the platelet indices were determined using a receiver operating characteristic curve. The Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of the potential predictors. RESULTS: Of the 168 patients, high platelet distribution width (PDW) and platelet count (PLT) levels were observed in 81 (48.21%) and 68 (40.48%) of the patients, respectively. An increased PDW was associated with the depth of invasion (T stage, P = 0.019), lymph node metastasis (N stage, P = 0.026), and clinical stage (P < 0.001). Moreover, the survival analysis showed that the overall survival of the patients with a PDW > 16.3 fL or platelet count > 266 × 10(9)/L was associated with a poorer prognosis (both P < 0.001). In the multivariate Cox regression model, the PDW (P < 0.001), PLT (P = 0.001), T stage (P < 0.001), N stage (P = 0.006), clinical stage (P = 0.005), and Epstein-Barr virus DNA (P = 0.039) were independent prognostic factors for the overall survival. CONCLUSIONS: The PDW and PLT are easily available via a routine blood test, and our study showed that the PDW and PLT could be prognostic predictors in NPC patients. However, further studies are required to confirm this conclusion.
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spelling pubmed-57397032017-12-28 Elevated pretreatment platelet distribution width and platelet count predict poor prognosis in nasopharyngeal carcinoma Xie, XueCheng Zeng, XiaoChun Cao, SuJuan Hu, XiaoMao Shi, QiaoJing Li, Dan Zhou, ShiYuan Gu, Ping Zhang, ZhongShan Oncotarget Research Paper BACKGROUND: Previous studies have demonstrated that platelets play a multifaceted role in cancer progression and metastasis. However, the value of platelet indices for predicting survival in nasopharyngeal carcinoma (NPC) patients remains unknown. The aim of this study was to evaluate the predictive significance of platelet indices in NPC cases. MATERIALS AND METHODS: A total of 168 patients who were diagnosed with NPC between January 2011 and June 2012 were recruited. The optimal cut-off values for the platelet indices were determined using a receiver operating characteristic curve. The Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of the potential predictors. RESULTS: Of the 168 patients, high platelet distribution width (PDW) and platelet count (PLT) levels were observed in 81 (48.21%) and 68 (40.48%) of the patients, respectively. An increased PDW was associated with the depth of invasion (T stage, P = 0.019), lymph node metastasis (N stage, P = 0.026), and clinical stage (P < 0.001). Moreover, the survival analysis showed that the overall survival of the patients with a PDW > 16.3 fL or platelet count > 266 × 10(9)/L was associated with a poorer prognosis (both P < 0.001). In the multivariate Cox regression model, the PDW (P < 0.001), PLT (P = 0.001), T stage (P < 0.001), N stage (P = 0.006), clinical stage (P = 0.005), and Epstein-Barr virus DNA (P = 0.039) were independent prognostic factors for the overall survival. CONCLUSIONS: The PDW and PLT are easily available via a routine blood test, and our study showed that the PDW and PLT could be prognostic predictors in NPC patients. However, further studies are required to confirm this conclusion. Impact Journals LLC 2017-11-20 /pmc/articles/PMC5739703/ /pubmed/29285316 http://dx.doi.org/10.18632/oncotarget.22528 Text en Copyright: © 2017 Xie et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Xie, XueCheng
Zeng, XiaoChun
Cao, SuJuan
Hu, XiaoMao
Shi, QiaoJing
Li, Dan
Zhou, ShiYuan
Gu, Ping
Zhang, ZhongShan
Elevated pretreatment platelet distribution width and platelet count predict poor prognosis in nasopharyngeal carcinoma
title Elevated pretreatment platelet distribution width and platelet count predict poor prognosis in nasopharyngeal carcinoma
title_full Elevated pretreatment platelet distribution width and platelet count predict poor prognosis in nasopharyngeal carcinoma
title_fullStr Elevated pretreatment platelet distribution width and platelet count predict poor prognosis in nasopharyngeal carcinoma
title_full_unstemmed Elevated pretreatment platelet distribution width and platelet count predict poor prognosis in nasopharyngeal carcinoma
title_short Elevated pretreatment platelet distribution width and platelet count predict poor prognosis in nasopharyngeal carcinoma
title_sort elevated pretreatment platelet distribution width and platelet count predict poor prognosis in nasopharyngeal carcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739703/
https://www.ncbi.nlm.nih.gov/pubmed/29285316
http://dx.doi.org/10.18632/oncotarget.22528
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