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Effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among HIV-infected patients, in the highly active antiretroviral therapy era

HIV-infected patients exposed to antiretroviral therapy (ART) have an increased risk for hyperlipidemia and cardiovascular disease. We performed a longitudinal, comprehensive, and population-based study to investigate the cumulative effect of different types of ART regimens on hyperlipidemia risk in...

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Autores principales: Tsai, Fuu-Jen, Cheng, Chi-Fung, Lai, Chih-Ho, Wu, Yang-Chang, Ho, Mao-Wang, Wang, Jen-Hsien, Tien, Ni, Liu, Xiang, Tsang, Hsinyi, Lin, Ting-Hsu, Liao, Chiu-Chu, Huang, Shao-Mei, Li, Ju-Pi, Lin, Jung-Chun, Lin, Chih-Chien, Chen, Jin-Hua, Liang, Wen-Miin, Lin, Ying-Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739740/
https://www.ncbi.nlm.nih.gov/pubmed/29290955
http://dx.doi.org/10.18632/oncotarget.22465
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author Tsai, Fuu-Jen
Cheng, Chi-Fung
Lai, Chih-Ho
Wu, Yang-Chang
Ho, Mao-Wang
Wang, Jen-Hsien
Tien, Ni
Liu, Xiang
Tsang, Hsinyi
Lin, Ting-Hsu
Liao, Chiu-Chu
Huang, Shao-Mei
Li, Ju-Pi
Lin, Jung-Chun
Lin, Chih-Chien
Chen, Jin-Hua
Liang, Wen-Miin
Lin, Ying-Ju
author_facet Tsai, Fuu-Jen
Cheng, Chi-Fung
Lai, Chih-Ho
Wu, Yang-Chang
Ho, Mao-Wang
Wang, Jen-Hsien
Tien, Ni
Liu, Xiang
Tsang, Hsinyi
Lin, Ting-Hsu
Liao, Chiu-Chu
Huang, Shao-Mei
Li, Ju-Pi
Lin, Jung-Chun
Lin, Chih-Chien
Chen, Jin-Hua
Liang, Wen-Miin
Lin, Ying-Ju
author_sort Tsai, Fuu-Jen
collection PubMed
description HIV-infected patients exposed to antiretroviral therapy (ART) have an increased risk for hyperlipidemia and cardiovascular disease. We performed a longitudinal, comprehensive, and population-based study to investigate the cumulative effect of different types of ART regimens on hyperlipidemia risk in the Taiwanese HIV/ART cohort. A total of 13,370 HIV-infected patients (2,674 hyperlipidemia and 10,696 non-hyperlipidemia patients) were recruited after matching for age, gender, and the first diagnosis date of HIV infection by using the National Health Insurance Research Database in Taiwan. Hyperlipidemia risk associated with cumulative ART use, ART adherence, and their combination was assessed. The matched hyperlipidemia group had a larger number of patients using ART and a higher incidence of comorbidities, specifically, respiratory disease and diabetes. Patients with high ART dosage and dose-dependent manner adherence, respectively, demonstrated an increased risk of hyperlipidemia. For single ART regimens, patients receiving nucleoside reverse-transcriptase inhibitors (NRTI/NRTI)- containing regimen had the highest hyperlipidemia risk, followed by protease inhibitor (PI)- containing and non-NRTI- containing regimens. For combination ART regimens, patients receiving a NRTI/NRTI + PI regimen had the highest hyperlipidemia risk. An increased cumulative drug dose was observed in patients who received the PI, NRTI/NRTI, NRTI, and NNRTI regimens in the hyperlipidemia group, when compared to the non-hyperlipidemia group. In conclusion, ART cumulative use, adherence, and regimen may affect hyperlipidemia risk among HIV-infected patients in a dose-dependent manner.
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spelling pubmed-57397402017-12-29 Effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among HIV-infected patients, in the highly active antiretroviral therapy era Tsai, Fuu-Jen Cheng, Chi-Fung Lai, Chih-Ho Wu, Yang-Chang Ho, Mao-Wang Wang, Jen-Hsien Tien, Ni Liu, Xiang Tsang, Hsinyi Lin, Ting-Hsu Liao, Chiu-Chu Huang, Shao-Mei Li, Ju-Pi Lin, Jung-Chun Lin, Chih-Chien Chen, Jin-Hua Liang, Wen-Miin Lin, Ying-Ju Oncotarget Research Paper HIV-infected patients exposed to antiretroviral therapy (ART) have an increased risk for hyperlipidemia and cardiovascular disease. We performed a longitudinal, comprehensive, and population-based study to investigate the cumulative effect of different types of ART regimens on hyperlipidemia risk in the Taiwanese HIV/ART cohort. A total of 13,370 HIV-infected patients (2,674 hyperlipidemia and 10,696 non-hyperlipidemia patients) were recruited after matching for age, gender, and the first diagnosis date of HIV infection by using the National Health Insurance Research Database in Taiwan. Hyperlipidemia risk associated with cumulative ART use, ART adherence, and their combination was assessed. The matched hyperlipidemia group had a larger number of patients using ART and a higher incidence of comorbidities, specifically, respiratory disease and diabetes. Patients with high ART dosage and dose-dependent manner adherence, respectively, demonstrated an increased risk of hyperlipidemia. For single ART regimens, patients receiving nucleoside reverse-transcriptase inhibitors (NRTI/NRTI)- containing regimen had the highest hyperlipidemia risk, followed by protease inhibitor (PI)- containing and non-NRTI- containing regimens. For combination ART regimens, patients receiving a NRTI/NRTI + PI regimen had the highest hyperlipidemia risk. An increased cumulative drug dose was observed in patients who received the PI, NRTI/NRTI, NRTI, and NNRTI regimens in the hyperlipidemia group, when compared to the non-hyperlipidemia group. In conclusion, ART cumulative use, adherence, and regimen may affect hyperlipidemia risk among HIV-infected patients in a dose-dependent manner. Impact Journals LLC 2017-11-15 /pmc/articles/PMC5739740/ /pubmed/29290955 http://dx.doi.org/10.18632/oncotarget.22465 Text en Copyright: © 2017 Tsai et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Tsai, Fuu-Jen
Cheng, Chi-Fung
Lai, Chih-Ho
Wu, Yang-Chang
Ho, Mao-Wang
Wang, Jen-Hsien
Tien, Ni
Liu, Xiang
Tsang, Hsinyi
Lin, Ting-Hsu
Liao, Chiu-Chu
Huang, Shao-Mei
Li, Ju-Pi
Lin, Jung-Chun
Lin, Chih-Chien
Chen, Jin-Hua
Liang, Wen-Miin
Lin, Ying-Ju
Effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among HIV-infected patients, in the highly active antiretroviral therapy era
title Effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among HIV-infected patients, in the highly active antiretroviral therapy era
title_full Effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among HIV-infected patients, in the highly active antiretroviral therapy era
title_fullStr Effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among HIV-infected patients, in the highly active antiretroviral therapy era
title_full_unstemmed Effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among HIV-infected patients, in the highly active antiretroviral therapy era
title_short Effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among HIV-infected patients, in the highly active antiretroviral therapy era
title_sort effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among hiv-infected patients, in the highly active antiretroviral therapy era
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739740/
https://www.ncbi.nlm.nih.gov/pubmed/29290955
http://dx.doi.org/10.18632/oncotarget.22465
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