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Effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among HIV-infected patients, in the highly active antiretroviral therapy era
HIV-infected patients exposed to antiretroviral therapy (ART) have an increased risk for hyperlipidemia and cardiovascular disease. We performed a longitudinal, comprehensive, and population-based study to investigate the cumulative effect of different types of ART regimens on hyperlipidemia risk in...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739740/ https://www.ncbi.nlm.nih.gov/pubmed/29290955 http://dx.doi.org/10.18632/oncotarget.22465 |
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author | Tsai, Fuu-Jen Cheng, Chi-Fung Lai, Chih-Ho Wu, Yang-Chang Ho, Mao-Wang Wang, Jen-Hsien Tien, Ni Liu, Xiang Tsang, Hsinyi Lin, Ting-Hsu Liao, Chiu-Chu Huang, Shao-Mei Li, Ju-Pi Lin, Jung-Chun Lin, Chih-Chien Chen, Jin-Hua Liang, Wen-Miin Lin, Ying-Ju |
author_facet | Tsai, Fuu-Jen Cheng, Chi-Fung Lai, Chih-Ho Wu, Yang-Chang Ho, Mao-Wang Wang, Jen-Hsien Tien, Ni Liu, Xiang Tsang, Hsinyi Lin, Ting-Hsu Liao, Chiu-Chu Huang, Shao-Mei Li, Ju-Pi Lin, Jung-Chun Lin, Chih-Chien Chen, Jin-Hua Liang, Wen-Miin Lin, Ying-Ju |
author_sort | Tsai, Fuu-Jen |
collection | PubMed |
description | HIV-infected patients exposed to antiretroviral therapy (ART) have an increased risk for hyperlipidemia and cardiovascular disease. We performed a longitudinal, comprehensive, and population-based study to investigate the cumulative effect of different types of ART regimens on hyperlipidemia risk in the Taiwanese HIV/ART cohort. A total of 13,370 HIV-infected patients (2,674 hyperlipidemia and 10,696 non-hyperlipidemia patients) were recruited after matching for age, gender, and the first diagnosis date of HIV infection by using the National Health Insurance Research Database in Taiwan. Hyperlipidemia risk associated with cumulative ART use, ART adherence, and their combination was assessed. The matched hyperlipidemia group had a larger number of patients using ART and a higher incidence of comorbidities, specifically, respiratory disease and diabetes. Patients with high ART dosage and dose-dependent manner adherence, respectively, demonstrated an increased risk of hyperlipidemia. For single ART regimens, patients receiving nucleoside reverse-transcriptase inhibitors (NRTI/NRTI)- containing regimen had the highest hyperlipidemia risk, followed by protease inhibitor (PI)- containing and non-NRTI- containing regimens. For combination ART regimens, patients receiving a NRTI/NRTI + PI regimen had the highest hyperlipidemia risk. An increased cumulative drug dose was observed in patients who received the PI, NRTI/NRTI, NRTI, and NNRTI regimens in the hyperlipidemia group, when compared to the non-hyperlipidemia group. In conclusion, ART cumulative use, adherence, and regimen may affect hyperlipidemia risk among HIV-infected patients in a dose-dependent manner. |
format | Online Article Text |
id | pubmed-5739740 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-57397402017-12-29 Effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among HIV-infected patients, in the highly active antiretroviral therapy era Tsai, Fuu-Jen Cheng, Chi-Fung Lai, Chih-Ho Wu, Yang-Chang Ho, Mao-Wang Wang, Jen-Hsien Tien, Ni Liu, Xiang Tsang, Hsinyi Lin, Ting-Hsu Liao, Chiu-Chu Huang, Shao-Mei Li, Ju-Pi Lin, Jung-Chun Lin, Chih-Chien Chen, Jin-Hua Liang, Wen-Miin Lin, Ying-Ju Oncotarget Research Paper HIV-infected patients exposed to antiretroviral therapy (ART) have an increased risk for hyperlipidemia and cardiovascular disease. We performed a longitudinal, comprehensive, and population-based study to investigate the cumulative effect of different types of ART regimens on hyperlipidemia risk in the Taiwanese HIV/ART cohort. A total of 13,370 HIV-infected patients (2,674 hyperlipidemia and 10,696 non-hyperlipidemia patients) were recruited after matching for age, gender, and the first diagnosis date of HIV infection by using the National Health Insurance Research Database in Taiwan. Hyperlipidemia risk associated with cumulative ART use, ART adherence, and their combination was assessed. The matched hyperlipidemia group had a larger number of patients using ART and a higher incidence of comorbidities, specifically, respiratory disease and diabetes. Patients with high ART dosage and dose-dependent manner adherence, respectively, demonstrated an increased risk of hyperlipidemia. For single ART regimens, patients receiving nucleoside reverse-transcriptase inhibitors (NRTI/NRTI)- containing regimen had the highest hyperlipidemia risk, followed by protease inhibitor (PI)- containing and non-NRTI- containing regimens. For combination ART regimens, patients receiving a NRTI/NRTI + PI regimen had the highest hyperlipidemia risk. An increased cumulative drug dose was observed in patients who received the PI, NRTI/NRTI, NRTI, and NNRTI regimens in the hyperlipidemia group, when compared to the non-hyperlipidemia group. In conclusion, ART cumulative use, adherence, and regimen may affect hyperlipidemia risk among HIV-infected patients in a dose-dependent manner. Impact Journals LLC 2017-11-15 /pmc/articles/PMC5739740/ /pubmed/29290955 http://dx.doi.org/10.18632/oncotarget.22465 Text en Copyright: © 2017 Tsai et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Tsai, Fuu-Jen Cheng, Chi-Fung Lai, Chih-Ho Wu, Yang-Chang Ho, Mao-Wang Wang, Jen-Hsien Tien, Ni Liu, Xiang Tsang, Hsinyi Lin, Ting-Hsu Liao, Chiu-Chu Huang, Shao-Mei Li, Ju-Pi Lin, Jung-Chun Lin, Chih-Chien Chen, Jin-Hua Liang, Wen-Miin Lin, Ying-Ju Effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among HIV-infected patients, in the highly active antiretroviral therapy era |
title | Effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among HIV-infected patients, in the highly active antiretroviral therapy era |
title_full | Effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among HIV-infected patients, in the highly active antiretroviral therapy era |
title_fullStr | Effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among HIV-infected patients, in the highly active antiretroviral therapy era |
title_full_unstemmed | Effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among HIV-infected patients, in the highly active antiretroviral therapy era |
title_short | Effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among HIV-infected patients, in the highly active antiretroviral therapy era |
title_sort | effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among hiv-infected patients, in the highly active antiretroviral therapy era |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739740/ https://www.ncbi.nlm.nih.gov/pubmed/29290955 http://dx.doi.org/10.18632/oncotarget.22465 |
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