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Exacerbation of diabetic cardiac hypertrophy in OVE26 mice by angiotensin II is associated with JNK/c-Jun/miR-221-mediated autophagy inhibition

Both diabetes and angiotensin II (Ang II) excess trigger cardiac remodeling and dysfunction, and diabetic cardiomyopathy. We hypothesized that cardiac hypertrophy associated with the development of diabetic cardiomyopathy is worsened by increased Ang II. Male type 1 diabetic OVE26 and wild-type mice...

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Detalles Bibliográficos
Autores principales:	Qian, Ling-Bo, Jiang, Sai-Zhi, Tang, Xiao-Qiang, Zhang, Jian, Liang, Ya-Qin, Yu, Hai-Tao, Chen, Jing, Xu, Zheng, Liu, Rui-Ming, Keller, Bradley B., Ji, Hong-Lei, Cai, Lu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739764/ https://www.ncbi.nlm.nih.gov/pubmed/29290979 http://dx.doi.org/10.18632/oncotarget.21302

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